Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates Cristina E. Mapp, MD a, Anthony A. Fryer, PhD,

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Presentation transcript:

Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates Cristina E. Mapp, MD a, Anthony A. Fryer, PhD, MRCPath b, Nicoletta De Marzo, MD c, Valeria Pozzato, MD c, Michele Padoan, MD c, Piera Boschetto, MD a, Richard C. Strange, PhD, FRCPath b, Anja Hemmingsen, MMSc b, Monica A. Spiteri, MD b Journal of Allergy and Clinical Immunology Volume 109, Issue 5, Pages 867-872 (May 2002) DOI: 10.1067/mai.2002.123234 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Frequency of the GSTP1 Val 105/Val 105 genotype in patients with no or mild versus moderate or severe AHR according to the duration of exposure to TDI. Groups were defined as follows: Non/mild AHR (shaded bars) , PD20 FEV1 methacholine greater than 700 μg; moderate/severe AHR (filled bars) , PD20 FEV1 methacholine less than 700 μg. Journal of Allergy and Clinical Immunology 2002 109, 867-872DOI: (10.1067/mai.2002.123234) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Association of GSTP1 Ile 105-Val 105 genotype frequencies with AHR in subjects exposed to TDI for longer than 10 years. Groups were defined as follows: Non/mild AHR (shaded bars) , PD20 FEV1 methacholine greater than 700 μg; moderate/severe AHR (filled bars) , PD20 FEV1 methacholine less than 700 μg. Ile/Ile + Ile/Val versus Val/Val : P = .033. Journal of Allergy and Clinical Immunology 2002 109, 867-872DOI: (10.1067/mai.2002.123234) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 Association of GSTP1 Ile 105-Val 105 genotype frequencies with asthma in subjects exposed to TDI for longer than 10 years. Groups were defined as follows: Nonasthmatic (shaded bars) , Asymptomatic subjects exposed to TDI; asthmatic (filled bars) , subjects exposed to TDI with documented TDI-induced asthma. Ile/Ile + Ile/Val versus Val/Val : P = .074. Journal of Allergy and Clinical Immunology 2002 109, 867-872DOI: (10.1067/mai.2002.123234) Copyright © 2002 Mosby, Inc. Terms and Conditions