Bobby Yanagawa, MD, PhD, Khaled D. Algarni, MD, MHSc, Steve K

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Presentation transcript:

Clinical, biochemical, and genetic predictors of coronary artery bypass graft failure Bobby Yanagawa, MD, PhD, Khaled D. Algarni, MD, MHSc, Steve K. Singh, MD, MSc, Saswata Deb, MD, Jessica Vincent, DipClinEpi, Randi Elituv, BSc, Nimesh D. Desai, MD, PhD, Karthikeyan Rajamani, PhD, Bruce M. McManus, MD, PhD, Peter P. Liu, MD, MSc, Eric A. Cohen, MD, Sam Radhakrishnan, MD, James D. Dubbin, MD, Leonard Schwartz, MD, Stephen E. Fremes, MD, MSc The Journal of Thoracic and Cardiovascular Surgery Volume 148, Issue 2, Pages 515-520.e2 (August 2014) DOI: 10.1016/j.jtcvs.2013.10.011 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Glutathione-s-transferase α3 (GSTα3) expression in human coronary arteries (CAs) and saphenous vein grafts (SVGs). Upper, GSTα3 expression seen in deep intimal layer (arrows) and adventitia (arrowheads) of atherosclerotic plaque regions of CA (original magnification ×4) but not in the nonatherosclerotic CAs (Insert; original magnification ×40). Lower, Gstα3 expression is present in the intima of the SVGs undergoing intimal proliferation (arrowheads; original magnification ×20) but not in the patent vein grafts (Insert; original magnification ×20). GSTA3 expression was more abundant in human atherosclerotic CAs (n = 10) than in the nonatherosclerotic CAs on quantitative image analysis (n = 6; P < .05). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 515-520.e2DOI: (10.1016/j.jtcvs.2013.10.011) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Positive and negative immunohistochemical controls for glutathione-S-transferase α3 expression. A, Murine kidney was used as a positive control (original magnification ×40) and B, a section of human saphenous vein graft as a negative control (original magnification ×20). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 515-520.e2DOI: (10.1016/j.jtcvs.2013.10.011) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions