Bigger Foot: Kaposi's Sarcoma Rekha R. Rapaka, MD, PhD, Max Fischer, MD, Thomas E. Finucane, MD, Agnes Mwakingwe, MD, PhD  The American Journal of Medicine  Volume 128, Issue 9, Pages 959-962 (September 2015) DOI: 10.1016/j.amjmed.2015.05.005 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 The Kaposi's sarcoma lesions on the patient's right lower extremity were quite varied and accompanied by right lower-extremity lymphedema. A, Multiple small nodular lesions were seen on the ankle and foot. B, Asymmetry in size was evident between the right and left lower extremities. C, Lesions were at different stages; 1 was large, ruptured, and scabbed. D, An ovoid plaque was evident on the leg. Note that no significant pigmentation difference exists between the color of the nodules and the patient's skin color. The American Journal of Medicine 2015 128, 959-962DOI: (10.1016/j.amjmed.2015.05.005) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 2 Tissue was taken from a nodular lesion for biopsy. A, Nodular dermal proliferation was identified (hematoxylin and eosin, 40×). B, Plump, spindle-shaped cells were arranged as fascicles with admixed erythrocytes (hematoxylin and eosin, 100× magnification). C, Strong and diffuse nuclear expression of Kaposi's sarcoma herpesvirus, also known as human herpesvirus-8, and latency-associated nuclear antigen (LANA) was noted (HHV-8/LANA immunostaining, 100×). The American Journal of Medicine 2015 128, 959-962DOI: (10.1016/j.amjmed.2015.05.005) Copyright © 2015 Elsevier Inc. Terms and Conditions