Amyloid‐associated gliosis in APPPS1‐21 transgenic mice.

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Invest. Ophthalmol. Vis. Sci ;55(7): doi: /iovs Figure Legend:

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Reduction in immune cell infiltration after stab wound injury in CCR2−/− mice increases proliferation at the injury site Reduction in immune cell infiltration.

Prostaglandin E2 (PGE2) induces no significant alteration in circadian locomotor activity. Prostaglandin E2 (PGE2) induces no significant alteration in.

Loss of SORCS1 and SORCS3 increases hypothalamic expression of Agrp and Klf4 Loss of SORCS1 and SORCS3 increases hypothalamic expression of Agrp and Klf4.

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Morphology of white adipose tissue and muscle in S1/3 KO mice of different ages Morphology of white adipose tissue and muscle in S1/3 KO mice of different.

Loss of Hdac3 impairs Ar signaling in mouse prostate tissues and has no effect on apoptosis Loss of Hdac3 impairs Ar signaling in mouse prostate tissues.

Juxtavascular astrocytes are enriched in nuclear Aryl hydrocarbon receptor immunostaining at the stab wound injury site in WT mice Juxtavascular astrocytes.

Activation of EphB4 by ephrinB2‐Fc prevents aberrant angiogenesis

Reduced astrocyte proliferation results in increased immune cell infiltration into the injured GM Reduced astrocyte proliferation results in increased.

Reduced scar formation in the injured GM of CCR2−/− mice

SERCA2 is a functional adaptor for the alternative toll‐like receptor 9 (TLR9) signalling in cardiomyocytes Co‐immunoprecipitated TLR9 with SERCA2 antibody.

Measurement of terminal restriction fragments (TRFs) in bone marrow cells from both parents and the G4 progeny. Measurement of terminal restriction fragments.

Fig. 2. Increased Aβ plaque load in 16-month-old APP/PS1;C3 KO mice.

Morphological analyses of peripheral blood and bone marrow cells isolated from leukemic mice. Morphological analyses of peripheral blood and bone marrow.

TRF2ΔBΔM induces apoptosis and senescence in the mouse liver.

Cognitive deficits in APPPS1‐21 mice.

Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice.

The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in.

Characterization of transgenic mice.

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

TNFR1 deficiency protects against morphological alterations in the choroid plexus of APP/PS1tg/wt mice determined by TEM TNFR1 deficiency protects against.

HSV‐1 depletes mt DNA and mt mRNA in infected Vero cells.

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Impaired fear extinction precedes memory decline in Fmn2 mutant mice

No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO Cre+ mice No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO.

Effects of GM1 on astroglial and microglial markers

Fads2−/− mice develop obesity resistance A–CBody size [cm] (nose‐tail root) and weight of male and female fads2−/− mice (age 4 months) differed by about.

TFE3 prevents diet‐induced obesity and metabolic syndrome

Smaller T cell zone FRC areas in aged spleens.

Impaired glucose tolerance in adult S1/3 KO mice on a normal chow

Beclin‐1 depletion reduces targeting of several outer kinetochore proteins. Beclin‐1 depletion reduces targeting of several outer kinetochore proteins.

Stromal fibromuscular AR regulates epithelium proliferation, ECM remodelling, neovasculature formation and immune cell infiltration in Pten deficient mice.

FFAT motif‐dependent recruitment of MOSPD2 in ER–endosome contacts by STARD3NL FFAT motif‐dependent recruitment of MOSPD2 in ER–endosome contacts by STARD3NL.

FFAT‐containing proteins recruit the ER‐resident MOSPD2 protein to interorganelle contact sites FFAT‐containing proteins recruit the ER‐resident MOSPD2.

Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice.

Volume 5, Issue 3, Pages (November 2013)

Age‐related amyloid deposition in APPPS1‐21 mice.

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Hdac3 deletion decreases AKT phosphorylation and tumor growth in Pten knockout prostate cancer Hdac3 deletion decreases AKT phosphorylation and tumor growth.

MOSPD2 silencing affects interorganelle contact sites organization

IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.

mGPDH is not essential to muscle development

Co‐expression of Sorcs1 and Sorcs3 in the hypothalamus

Fig. 3. Morphological changes associated with glial activation were reduced in 16-month-old APP/PS1;C3 KO mice. Morphological changes associated with glial.

Kurt W. Prins et al. BTS 2016;1: T-Tubule Derangements in mdx Mice Are Associated With JPH-2 Misregulation (A) Representative confocal images of.

Smoc2 marks intestinal stem cells in vivo.

Target engagement of the systemic Stat3 inhibitor in APP/PS1 mice

Absence of a vestibular phenotype in CIB2−/− mice

MiR‐34a‐5p functionally contributes to arrested lung alveolarization in response to hyperoxia miR‐34a‐5p functionally contributes to arrested lung alveolarization.

ZBTB48 is required for MTFP1 expression

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CAIA is attenuated in Nrdc – / – mice.

Neuronal ATM level is reduced in mouse models of AD

Transection of the chorda tympani depletes acinar cells at 7 days

GM1 decreases neuropathology and weight loss in R6/2 mice

P2X4R blockade increases pro‐inflammatory gene expression after EAE

FGFR1 and TGFβ signaling activity in smooth muscle cells in a mouse atherosclerosis model FGFR1 and TGFβ signaling activity in smooth muscle cells in a.

Amyloid pathology in APP/PSEN1 and APP/PSEN1/APOEnull mice.

Ab-dependent synaptic loss and neuritic dystrophies in adult APP/PSEN1 and APP/PSEN1/APOEnull mice. Ab-dependent synaptic loss and neuritic dystrophies.

KlbHET mice exhibit altered estrous cycle and subfertility

Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse myocardium. Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse.

Deletion of HtrA1 does not alter vascular or immune cell morphology or distribution in the young-adult mouse neocortex. Deletion of HtrA1 does not alter.

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

Fig. 3. Morphological changes associated with glial activation were reduced in 16-month-old APP/PS1;C3 KO mice. Morphological changes associated with glial.

Abnormal morphologies are prevented by overexpression of CaN inhibitory peptide AKAP79 in APP/PS1 mouse brain. Abnormal morphologies are prevented by overexpression.

PC loss in Nhe6-null mouse cerebellum, female and male.

Fig. 2. SUS reduces Aβ plaques in an AD mouse model.

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Amyloid‐associated gliosis in APPPS1‐21 transgenic mice. Amyloid‐associated gliosis in APPPS1‐21 transgenic mice. (A) Iba1‐positive microglia and Congo red‐stained amyloid in the neocortex of 1‐, 2‐, 4‐ and 8‐month (mo)‐old female transgenic mice. Activated and hypertrophic microglia appear concomitantly with the appearance of the first plaques and are tightly clustered around the amyloid. Scale bar, 100 μm. (B) High magnification reveals micoglia clustered around a plaque in an 8‐month‐old mouse. Scale bar, 20 μm. (C) Stereological quantification of total number of Iba1‐positive cells in the neocortex of female APPPS1‐21 mice (n=5/group) and non‐transgenic control mice (n=3/group). Two‐way analysis of variance showed significant effects of age (F2,18=7.6), transgene (F1,18=47.3) and age × transgene (F2,18=16.4; all P<0.01). Significant differences between transgenic and control were found at 4 and 8 months; **P<0.01. wt, wild type. Rebecca Radde et al. EMBO Rep. 2006;7:940-946 © as stated in the article, figure or figure legend