Approaching the Asymptote: 20 Years Later

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Approaching the Asymptote: 20 Years Later Ruslan Medzhitov Immunity Volume 30, Issue 6, Pages 766-775 (June 2009) DOI: 10.1016/j.immuni.2009.06.004 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Pattern Recognition Receptors Major classes of mammalian pattern recognition receptors and some of their representative microbial ligands are shown. Secreted pattern recognition molecules activate complement and function as opsonins. Transmembrane and intracellular receptors trigger signaling pathways for innate host defense and activate adaptive immune responses. Mechanisms of inflammasome activation are still being defined. NLRs, NOD-like receptors; CRD, carbohydrate recognition domain; ITAM, immunoreceptor tyrosine-based activation motif. Immunity 2009 30, 766-775DOI: (10.1016/j.immuni.2009.06.004) Copyright © 2009 Elsevier Inc. Terms and Conditions