DNA Mutations and Repair

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Presentation transcript:

DNA Mutations and Repair Chapter 17

Chernobyl, April 26th, 1986 Equal to medium nuclear bomb

Radiation (Techa River) Hiroshima (Aug. 6th, 1945)

DNA Repair: general characteristics Double stranded DNA Redundancy of pathways

Types of DNA repair Mismatch repair Direct Repair Base-Excision Repair Nucleotide Excision Repair

Mismatch repair Mut H Recognize GATC hemi-methylation Mut S Mut L

A closer look at mismatch repair

DIRECT REVERSAL REPAIR Direct Repair

BASE EXCISION REPAIR

BASE EXCISION REPAIR

Nucleotide Excision Repair

Xeroderma pigmentosum UV light damage Autosomal recessive Error in DNA excision-repair enzymes

Hereditary Non-Polyposis Colon Cancer HNPCC 15% of all colon cancers

Li-Fraumeni P-53 mutation

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