Ghrelin—a new player in glucose homeostasis?

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Ghrelin—a new player in glucose homeostasis? Rexford S. Ahima Cell Metabolism Volume 3, Issue 5, Pages 301-302 (May 2006) DOI: 10.1016/j.cmet.2006.04.006 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Model for actions of ghrelin on glucose homeostasis Based on deletion of ghrelin, it appears ghrelin acts on pancreatic β cells to inhibit insulin production and secretion, possibly by increasing UCP2. Ghrelin also inhibits glucose uptake in muscle and adipose tissue and stimulates glucose production by the liver. Pharmacological stimulation of appetite by ghrelin was not supported in this genetic model. Ghrelin did not affect feeding or weight. Cell Metabolism 2006 3, 301-302DOI: (10.1016/j.cmet.2006.04.006) Copyright © 2006 Elsevier Inc. Terms and Conditions