Tissue Factor Pathway Inhibitor Ixolaris Improves Disease Outcome in Progressive SIVsab-infected Pigtail Macaques Tianyu He Non-pathogenic Pathogenic Pandrea.

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Tissue Factor Pathway Inhibitor Ixolaris Improves Disease Outcome in Progressive SIVsab-infected Pigtail Macaques Tianyu He Non-pathogenic Pathogenic Pandrea I, et al. Blood. 2012

Tissue factor (TF) expression increases in chronic SIV infection. Funderburg NT, et al. Blood. 2010 Tissue factor (TF) expression increases in chronic SIV infection. TF expression increases not only in blood, but also in mucosal tissue.

In vitro specificity of Ixolaris In vivo efficacy of Ixolaris Conclusion: TF bridges hypercoagulation and IA/INFL during chronic SIV infection. Blocking TF with Ixolaris improves clinical outcome of progressive SIV infection.

Conclusion Chronic HIV/SIV Infection Immune activation and inflammation Comorbidities Hypercoagulation

Acknowledgement Funding Apetrei/Pandrea lab NIH University of Vermont George Haret-Richter Tammy Dunsmore Benjamin Policicchio Kevin Raehtz Egidio Brocca-Cofano Cuiling Xu NIH Bruno Andrade Ivo Francischetti Dongying Ma Irini Sereti Melissa Schechter University of Vermont Russel Tracy Universidade de Lisboa Ruy Ribeiro Funding Intramural Research Program, NIAID; Bench-to-Bedside award R01HL117715-10S1; R01 HL123096; R01 HL117715; R01 AI119346; R01AI104373