P. Dabir, S. Dabir, K.N. Krithika, K. Goswami, M.V.R. Reddy 

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Presentation transcript:

Immunoprophylactic evaluation of a 37-kDa Brugia malayi recombinant antigen in lymphatic filariasis  P. Dabir, S. Dabir, K.N. Krithika, K. Goswami, M.V.R. Reddy  Clinical Microbiology and Infection  Volume 12, Issue 4, Pages 361-368 (April 2006) DOI: 10.1111/j.1469-0691.2006.01362.x Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Reactivity of human sera from different groups with rBm-SL3 protein in ELISA. MF, microfilaraemia; EN, endemic normal; NEN, non-endemic normal. Clinical Microbiology and Infection 2006 12, 361-368DOI: (10.1111/j.1469-0691.2006.01362.x) Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Filarial-specific IgG subclasses in sera from different groups. Bars represent geometric mean; absorbance values of endemic normals (En), □; microfilaraemics (Mf), clinical cases (Cl), ▪. The statistical significance was calculated by Kruskal–Wallis test. Clinical Microbiology and Infection 2006 12, 361-368DOI: (10.1111/j.1469-0691.2006.01362.x) Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 (a) IFN-γ (b) IL-10 and (c) IL-4 levels in the culture supernatants of rBm-SL3-stimulated peripheral blood mononuclear cells (PBMCs) from microfilaraemics (Mf), clinical filarial cases (Cl) and endemic normal (En) individuals. Bars represent the geometric mean levels in each case. The statistical significance was calculated by Kruskal–Wallis test. Clinical Microbiology and Infection 2006 12, 361-368DOI: (10.1111/j.1469-0691.2006.01362.x) Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions