RNA-Directed DNA Methylation: Getting a Grip on Mechanism Judith Bender  Current Biology  Volume 22, Issue 10, Pages R400-R401 (May 2012) DOI: 10.1016/j.cub.2012.04.010 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 A mechanistic model for RNA-dependent DNA methylation. RNA-dependent DNA methylation requires transcription through the target region, mediated in plants by Pol V. DMS3, DMS11, and perhaps a partner protein (?) could form a ring that promotes Pol V processivity by gripping together the RNA transcript and template DNA. Asterisks mark potential targets for base pairing with a small RNA protein complex. Current Biology 2012 22, R400-R401DOI: (10.1016/j.cub.2012.04.010) Copyright © 2012 Elsevier Ltd Terms and Conditions