Repair of mtDNA in Vertebrates

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Repair of mtDNA in Vertebrates Daniel F. Bogenhagen The American Journal of Human Genetics Volume 64, Issue 5, Pages 1276-1281 (May 1999) DOI: 10.1086/302392 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Common pathway for BER. The sequence context shown is appropriate for repair of a uracil residue in DNA, initiated by action of UDG. A single BER pathway has been documented for repair of bacterial DNA, for the nuclear pol β–dependent pathway and for mtDNA repair. An alternative “long patch” repair pathway, dependent on proliferating-cell nuclear antigen, also exists for eukaryotic nuclear DNA “dRP” denotes the deoxyribose phosphate group excised from the DNA. The complementary strand of the DNA duplex is not shown. (For other details, see the text.) The American Journal of Human Genetics 1999 64, 1276-1281DOI: (10.1086/302392) Copyright © 1999 The American Society of Human Genetics Terms and Conditions