Poly Ion Complex assemblies-PICs Objectif : former des associations de polymères par interactions ioniques plutôt que par effet hydrophobe + or.

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Presentation transcript:

Poly Ion Complex assemblies-PICs Objectif : former des associations de polymères par interactions ioniques plutôt que par effet hydrophobe + or Double-hydrophilic block copolymer with one charged block Transport de molécules Formation de matériaux Polyelectrolyte Mn+

Poly Ion Complex assemblies-PICs PEO -PAA DGL

Poly Ion Complex assemblies-PICs H2PO4- 100nm 100nm D ̴ 22-27 nm

Polymer based Nanocarriers Dh (nm)  (mV) PEO(2000)-PCL(2800) 20 -10 PEO(5000)-PCL(4000) 25 PEO (5000)-PCL (11000) 165.8 - PEO(2400)-PDLLA(2000) 30 -2.4 PEO(3100)-PS(2300) -1.8 PEO(1400) PMMA (5600) 633.8 nanoprecipitation nanoprecipitation , dialysis or film rehydration /extrusion

Hybrid Nanocarriers GUV Scale bar: 200 nm Scale bar: 10 mm 35 mol %

Evaporation or dialysis Preparation Methods Cosolvent Method Film rehydration Evaporation or dialysis Solvent Dissolution Addition to water or reverse Polymer Photosensitizer Dissolution Polymer Addition of water Evaporation

Variation 5x stronger // literature Mechanical stress induced by a light-responsive hydrogel Collaborations : C. Lorenzo (ITAV), C. Galès (I2MC, INSERM) Résultats : UV Vis 50% change 30% change Variation 5x stronger // literature