Volume 82, Issue 10, Pages (November 2012)

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Volume 82, Issue 10, Pages 1044-1045 (November 2012) Journal Club Kidney International Volume 82, Issue 10, Pages 1044-1045 (November 2012) DOI: 10.1038/ki.2012.355 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure Model for the functional contribution of Runx2 to vascular calcification. Oxidative stress induces the expression of Runx2 in VSMCs, which directly promotes osteogenic differentiation and calcification of VSMCs in vitro and in vivo. In addition, increased Runx2 directly upregulates the expression of receptor activator of nuclear factor-kB ligand (RANKL) in VSMCs by binding to the RANKL promoter, which in turn promotes infiltration of macrophages and formation of vascular osteoclasts in the calcified atherosclerotic lesions. Abbreviations: MΦ, macrophage; TRAP, tartrate-resistant acid phosphatase. Kidney International 2012 82, 1044-1045DOI: (10.1038/ki.2012.355) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure Peroxidasin is critical for collagen IV and basement membrane integrity. (a) Confocal fluorescence microscopy images of Drosophila anterior midgut using a collagen IV GFP protein trap line (vikingG454) to delineate collagen IV distribution. Representative sections from wild-type Pxn+/+, heterozygote Pxn+/− (Pxn+/f07229), and mutant Pxn−/− (Pxnf07229/f07229) flies are shown. Distorted and torn collagen IV networks (arrows) with gross defects (‘holes’) in the circumferential muscle layer (asterisks) typified Pxn−/− sections. Scale bars, 10 mm. (b) Immunoblot of collagenase-solubilized basement membrane isolated from Drosophila Pxn+/− and Pxn−/− larvae. Kidney International 2012 82, 1044-1045DOI: (10.1038/ki.2012.355) Copyright © 2012 International Society of Nephrology Terms and Conditions