Kristin G. Anderson, Ingunn M. Stromnes, Philip D. Greenberg

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Presentation transcript:

Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies Kristin G. Anderson, Ingunn M. Stromnes, Philip D. Greenberg Cancer Cell Volume 31, Issue 3, Pages 311-325 (March 2017) DOI: 10.1016/j.ccell.2017.02.008 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Overview of Obstacles in the Tumor Microenvironment that Interfere with T Cell Trafficking and Function Cancer Cell 2017 31, 311-325DOI: (10.1016/j.ccell.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Metabolic Perturbations within Tumor Cells Modulate the Tumor Microenvironment to Limit Nutrient Availability and Generate Metabolic Byproducts that Suppress T Cell Function Cancer Cell 2017 31, 311-325DOI: (10.1016/j.ccell.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 3 Drivers of T Cell Dysfunction in Tumors Cancer Cell 2017 31, 311-325DOI: (10.1016/j.ccell.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions