Kristin G. Anderson, Ingunn M. Stromnes, Philip D. Greenberg 

Slides:



Advertisements
Similar presentations
Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.
Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics  Angelika S. Rambold, Sarah.
Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.
Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.
Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.
Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.
MiR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells Mathieu Neault, Frédérick A. Mallette, Stéphane Richard Cell.
The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel
Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:
The Current Role of Operative Venous Thrombectomy in Deep Vein Thrombosis Anthony J. Comerota Seminars in Vascular Surgery Volume 25, Issue 1, Pages 2-12.
Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors Kunyoo Shin, Agnes Lim, Chen.
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.
Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.
Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel
Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.
Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages
T-ALL: Home Is where the CXCL12 Is
Liver Cancer Checks in When Bile Acid Clocks Out
Cutaneous Cancer Stem Cells: β-Catenin Strikes Again
A Novel Link between Inflammation and Cancer
Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer
Tumor Microenvironment: No Effector T Cells without Dendritic Cells
Intravascular Survival and Extravasation of Tumor Cells
Kenneth L. Scott, Scott Powers  Cancer Cell 
Maša Alečković, Yibin Kang  Cancer Cell 
An Alternative Sugar Fuels AML
Radiotherapy Complements Immune Checkpoint Blockade
Antagonizing ClpP: A New Power Play in Targeted Therapy for AML
Esther Bridges, Adrian L. Harris  Cancer Cell 
Cliques and Schisms of Cancer Genes
MDS Is a Stem Cell Disorder After All
Tipping the Balancing ACT
Volume 26, Issue 1, Pages 1-2 (July 2014)
Pontine Infantile Glioma Simplified
New Views into the Genetic Landscape of Metastatic Breast Cancer
Cutaneous Cancer Stem Cells: β-Catenin Strikes Again
The Amazing and Deadly Glioma Race
Copyright © 2012, Elsevier Inc. All rights Reserved.
Lung Cancer: A Wily Genetic Opponent
Copyright © 2012, Elsevier Inc. All rights Reserved.
HIV Drug to Aid Melanoma Therapies?
YAP/TAZ at the Roots of Cancer
Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy
Modifying Mitochondrial tRNAs: Delivering What the Cell Needs
AML Therapy: Wake Up the Guardian and Cut Loose the Executioners
Principles and Strategies for Developing Network Models in Cancer
Copyright © 2012, Elsevier Inc. All rights Reserved.
Kenneth L. Scott, Scott Powers  Cancer Cell 
Shifting the Evolving CAR T Cell Platform into Higher Gear
T Cell Dysfunction in Cancer
Pancreatic Cancer: Planning Ahead for Metastatic Spread
Splicing and Dicing MYC-Mediated Synthetic Lethality
Chapter 64 - Renal Calcium Metabolism
Will Bailis, Justin A. Shyer, Michael Chiorazzi, Richard A. Flavell 
Chapter 29 - Stem Cells and Generation of New Cells in the
Macrophage Metabolism Shapes Angiogenesis in Tumors
Presentation transcript:

Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies  Kristin G. Anderson, Ingunn M. Stromnes, Philip D. Greenberg  Cancer Cell  Volume 31, Issue 3, Pages 311-325 (March 2017) DOI: 10.1016/j.ccell.2017.02.008 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Overview of Obstacles in the Tumor Microenvironment that Interfere with T Cell Trafficking and Function Cancer Cell 2017 31, 311-325DOI: (10.1016/j.ccell.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Metabolic Perturbations within Tumor Cells Modulate the Tumor Microenvironment to Limit Nutrient Availability and Generate Metabolic Byproducts that Suppress T Cell Function Cancer Cell 2017 31, 311-325DOI: (10.1016/j.ccell.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 3 Drivers of T Cell Dysfunction in Tumors Cancer Cell 2017 31, 311-325DOI: (10.1016/j.ccell.2017.02.008) Copyright © 2017 Elsevier Inc. Terms and Conditions