Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer

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Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer Michelle Monje Cancer Cell Volume 31, Issue 1, Pages 1-2 (January 2017) DOI: 10.1016/j.ccell.2016.12.008 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Innervation Drives Enteric Cancer Growth Nerve growth factor (NGF) secreted by enteric cancer cells promotes cholinergic innervation of the tumor microenvironment, while acetylcholine (Ach) released from invading nerves promotes cancer cell proliferation via upregulated Wnt signaling. Feedforward effects of Ach on NGF expression and subsequently increased recruitment of nerves to the tumor drive enteric cancer initiation and growth. Illustration by Sarah Chen. Cancer Cell 2017 31, 1-2DOI: (10.1016/j.ccell.2016.12.008) Copyright © 2017 Elsevier Inc. Terms and Conditions