How drugs of abuse disrupt cellular communication

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Presentation transcript:

How drugs of abuse disrupt cellular communication Cells Talking Smack: How drugs of abuse disrupt cellular communication From Research to Rehab: A Town Hall Meeting on Substance Use and Young People Dr. Tricia Hardt Smith hardtta@vcu.edu Copyright © Dr. Tricia Smith 2016

What we know about Drugs & Addiction… ? ? ? ? ? ? © Tricia H. Smith PhD.

But first, let’s take a closer look… ? © Tricia H. Smith PhD.

Extracellular signal molecules: hormones, neurotransmitter, DRUGS! Cells TALK! © Tricia H. Smith PhD.

Receptors Adapt! Leads to drug tolerance! Can lead to drug dependence! Figure by T Hardt Smith. Introduction to Neuroendocrinology © Cambridge Press © Tricia H. Smith PhD.

Q: What happens when we take away the drug? Repeated Administration Control Q: What happens when we take away the drug? A: WITHDRAWAL Zastrow et. al. (1996) The Journal of Biological Chemistry © Tricia H. Smith PhD.

Drugs cause real, measurable changes at the cellular level! Every time we take a drug, any drug, we change how our cells behave! We can’t ‘get it out of our system!’ Addiction is not something cells can ‘snap out of’! It’s no longer about the high or the consequences! During addiction & withdrawal we need medical help! © Tricia H. Smith PhD.

Receptors can Recover! The Journal of Neuroscience, 21(23):9414-9418. 200126 © Tricia H. Smith PhD.

Questions?