Dynamics of Cytomegalovirus (CMV) Plasma DNAemia in Initial and Recurrent Episodes of Active CMV Infection in the Allogeneic Stem Cell Transplantation Setting: Implications for Designing Preemptive Antiviral Therapy Strategies  Beatriz Muñoz-Cobo, Carlos Solano, Elisa Costa, Dayana Bravo, María Ángeles Clari, Isabel Benet, María José Remigia, Juan Montoro, David Navarro  Biology of Blood and Marrow Transplantation  Volume 17, Issue 11, Pages 1602-1611 (November 2011) DOI: 10.1016/j.bbmt.2011.08.014 Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Initial episodes of active CMV infection that resolved spontaneously in which the kinetics of CMV plasma DNA clearance followed an exponential decay function. Black circles are data points. The line of best fit is shown. Day 0 represents the day of the first positive PCR result. Biology of Blood and Marrow Transplantation 2011 17, 1602-1611DOI: (10.1016/j.bbmt.2011.08.014) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) Kinetics of CMV plasma DNAemia in initial episodes of active CMV infection that resolved spontaneously. A ≥3-fold increase of CMV DNA load between the values in the first and second PCR positive specimens was documented in only 2 episodes (B). Early kinetics of CMV plasma DNAemia in initial episodes of active CMV infection that were eventually treated preemptively with antivirals (n = 17), before initiation of therapy (C). In 5 of these episodes (white triangles) CMV DNA load rapidly decreased following instauration of antiviral therapy in 5 episodes; in the remaining 12 episodes, a delayed response to therapy was observed (black diamonds). Day 0 represents the day of the first positive PCR result. Biology of Blood and Marrow Transplantation 2011 17, 1602-1611DOI: (10.1016/j.bbmt.2011.08.014) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 (A) Kinetics of CMV plasma DNAemia in recurrent episodes of active CMV infection that resolved spontaneously. (B) Kinetics of CMV plasma DNAemia in initial episodes of active CMV infection that required preemptive antiviral therapy before initiation of treatment. Day 0 represents the day of the first positive PCR result. Biology of Blood and Marrow Transplantation 2011 17, 1602-1611DOI: (10.1016/j.bbmt.2011.08.014) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions