Sandhya Pruthi, MD, Vania K. Stafyla, MD, Stephen W

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Presentation transcript:

Primary Mammary (Non-Hodgkin) Lymphoma Presenting as Locally Advanced Breast Cancer Sandhya Pruthi, MD, Vania K. Stafyla, MD, Stephen W. Phillips, MD, Luis F. Porrata, MD, Carol A. Reynolds, MD Mayo Clinic Proceedings Volume 79, Issue 10, Pages 1310-1314 (October 2004) DOI: 10.4065/79.10.1310 Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 1 Asymmetrical enlargement of left breast with erythema (left) and peau d'orange (right). Mayo Clinic Proceedings 2004 79, 1310-1314DOI: (10.4065/79.10.1310) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 2 Bilateral mammography shows a large, high-density, poorly defined mass in the central and lateral aspects of the left breast. A nodule with benign features is evident in the lower outer quadrant of the right breast. Left, Craniocaudal (CC) view. Right, Mediolateral oblique (MLO) view. L = left; R = right. Mayo Clinic Proceedings 2004 79, 1310-1314DOI: (10.4065/79.10.1310) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 3 Malignant lymphoma, diffuse large B-cell type. Left, Tumor cells diffusely infiltrating breast parenchyma (hematoxylin-eosin, original magnification ×50). Right, Diffuse infiltrate is composed of tumor cells with prominent nucleoli and scant cytoplasm (hematoxylineosin, original magnification ×200). Mayo Clinic Proceedings 2004 79, 1310-1314DOI: (10.4065/79.10.1310) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 4 Malignant lymphoma, diffuse large B-cell type. Tumor cells show strong reactivity with B-cell marker CD20 (immunohistochemical CD20 stain, original magnification ×200). Mayo Clinic Proceedings 2004 79, 1310-1314DOI: (10.4065/79.10.1310) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 5 Postchemotherapy bilateral mammography shows a marked reduction in the size of the left breast mass. Left, Craniocaudal (CC) view. Right, Mediolateral oblique (MLO) view. L = left; R = right. Mayo Clinic Proceedings 2004 79, 1310-1314DOI: (10.4065/79.10.1310) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions