Arachidonate Metabolism

Slides:



Advertisements
Similar presentations
بسم الله الرحمن الرحيم.
Advertisements

D3-Analgesics By Caroline Bexfield and Juan David Posada.
Awatif B. Al-Backer. Inflammation Definition: It is a protective response against injury which can be chemicals, mechanical, infectious, or immunological.
Eicosanoid Synthesis Molecular Biochemistry II
Synthesis, functions and
Orientation… Immunology can be studied at the level of molecules, cells, tissues & organs, organ systems & organisms. Can it be studied at the level of.
Analgesic Nephropathy A. Background NSAIDs: Overview and clincial use Targets of NSAIDs: The Cyclooxygenase (COX) enzymes The role of prostaglandins.
SYNTHESIS OF AN ARACHIDONIC ACID ANALOG. Arachidonic Acid Cascade The biological actions of arachidonic acid have essentially been attributed to the conversion.
Prostaglandins and Related Compounds 1Dr. Nikhat Siddiqi.
BIOC 460 DR. TISCHLER LECTURE 34 SYNTHESIS & PROCESSING OF FATS.
Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids.
Eicosanoid Metabolism Medical Biochemistry Lecture #50.
BIOCHEMISTRY LECTURES. Space-filling models of (A) palmitate (C16, saturated) and (B) oleate (C18, unsaturated). The cis double bond in oleate produces.
Steroid Hormones Cholesterol Starting material.
Eicosanoids Dr.S.Chakravarty ,MD.
© 2011 Pearson Education, Inc. 1 Organic Chemistry 6 th Edition Paula Yurkanis Bruice Chapter 27 The Organic Chemistry of Lipids.
Metabolism of Unsaturated Fatty Acids & Eicosanoids
Chemical Mediators of Inflammation
EICOSANOIDS (prostaglandins, thromboxanes, leukotrienes)
Complex Lipid Metabolism
Chapter 10.3: Lipids as Signals, Cofactors, and Pigments
1 Chapter 8: Outline 8.1 Fatty Acids 8.2 Waxes 8.3 Triglycerides (or triacylglyceries) 8.4 Phospholipids and Glycolipids 8.5 Steroids 8.6 Eicosanoids 8.7.
ECDA August STEROIDS AND HORMONES STEROIDS AND HORMONES  Steroids and hormones are alicyclic compounds, all of which are derivatives of a fused.
NSAIDS – Aspirin, Ibuprofen, Celebrex and Beyond.
10.3 Lipids as Signals, Cofactors, and Pigments. Biologically active lipids Active roles of lipids in metabolic traffic 1. Hormones or intracellular messengers.
Lipids.
Overview  Eicosanoids are a large group of autocoids with potent effects on virtually every tissue in the body  these agents are derived from metabolism.
Prostaglandins, cyclo-oxygenase and the GIT HPETE PGH.
Prostaglandin, Leukotriene, and Thromboxane Synthesis Eric Niederhoffer SIU-SOM Linoleic acid Thromboxane A 2 synthase Lipoxygenase Arachidonic acid Prostaglandin.
Some naturally occurring fatty acids in animals
Biological Lipids and Bilayers Lipids are nearly insoluble in Water –Form Biological membranes –Regulate solute flow and signalling –Provide concentrated.
C HAPTER 13 – L IPIDS – By: Mackenzie Stuck & Carlie Strawser.
COO - CH 2 COO - CH 2 C COO - O AcCoA COO - CH 2 OC HCOO - CH 2 CH 3 C-SCoA O COO - CH 2 C COO - O CH 2 HC COO - OH COO - CH 3 C O CO2CO2 COO - CH 2 C.
BIOCHEMISTRY LECTURES. Figure Stages in the extraction of energy from foodstuffs.
Prostaglandin, Leukotriene, and Thromboxane Synthesis Eric Niederhoffer SIU-SOM Pathway overview Prostaglandin receptors Pathway details Differential actions.
NSAIDs.
The Cholesterol Content of Selected Meats and Dairy Products. Cholesterol and fats transported thru bloodstream in the form of round particles called.
Synthesis of Eicosanoids, Glycerolipids and Isoprenoids
Prostaglandins& Related Compounds. Objectives Origin of ecosanoids Ecosanoids role Overview of the structure Role of phospholipase A2 Cyclooxgenase isoenzymes.
Prostaglandins & Related compounds. EICOSANOIDS Compounds that originate from polyunstaurated fatty acids with 20 carbons Prostaglandins (PG) Prostaglandins.
Metabolism of dietary lipids Biochemistry Department.
Prostaglandins& Related Compounds. Objectives Origin of ecosanoids Ecosanoids role Overview of the structure Role of phospholipase A2 Cyclooxgenase isoenzymes.
Eicosanoids. Deficiency symptoms in the absence of essential fatty acids from the diet: Nonlipid diet plus vitamins A and D Rat ––––––––––––––––––––––––––––––––
The Organic Chemistry of Lipids
Prostaglandins, Leukotrienes, and Eicosanoids
Eicosanoids.
Prostaglandins and Related Compounds
Inflammation lecture 4 Dr Heyam Awad FRCPath.
“Traditional NSAIDs” versus “COXIBs”
Jenna Booth, Christa Beveridge, Abigail Ruths, and Paula Cook
Biological Membranes.
Prostaglandin, Leukotriene, and Thromboxane Synthesis
Biological Membranes.
Eicosanoids The eicosanoids include: the prostaglandins thromboxanes
Eicosanoid Synthesis Molecular Biochemistry II
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Metabolic Pathways A metabolic pathway begins with a specific molecule and ends with a product Each step is catalyzed by a specific enzyme- importance.
BIOCHEMISTRY LECTURES
Chemical Mediators Dr Shoaib Raza.
Eicosanoid molecules (PGs, TXs, LTs).
Chapter VI Eicosanoids (Prostaglandis)
Prostaglandins and leucotreines
Eicosanoid molecules (PGs, TXs, LTs).
Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in balloon-injured rat carotid arteries  Jens W Fischer,
Lipoxins: Pro-resolution lipid mediators in intestinal inflammation
Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)
S. Van Biervliet, J.P. Van Biervliet, E. Robberecht, A. Christophe 
Volume 71, Issue 11, Pages (June 2007)
Resolving Lipids: Lipoxins Regulate Reverse Cholesterol Transport
PROSTAGLANDINS.
Presentation transcript:

Arachidonate Metabolism Title slide - C20 metabollism

Eicosanoid Function Inflammatory response Pain & fever Regulate blood pressure Induce blood clotting Induce labor Regulate wake/sleep Six functions of C20-derived compounds

Prostaglandin structures.

The synthesis of prostaglandin precursors.

Recovery of arachidonic acid from membrane phospholipids.

The two biosynthetic pathways: cyclic & linear.

The cyclic pathway with the site of action of aspirin.

The reactions catalyzed by PGH2 synthase with two enzyme activities on the same protein: cyclooxygenase and peroxidase.

The X-ray structure of PGH2.

NSAID structures.

Aspirin acetylates ser 530 and blocks the cyclooxygenase activity.

The lipoxygenase-catalyzed oxidation of arachidonate to 5-HPETE.

The formation of leukotrienes.