Arachidonate Metabolism

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Presentation transcript:

Arachidonate Metabolism Title slide - C20 metabollism

Eicosanoid Function Inflammatory response Pain & fever Regulate blood pressure Induce blood clotting Induce labor Regulate wake/sleep Six functions of C20-derived compounds

Prostaglandin structures.

The synthesis of prostaglandin precursors.

Recovery of arachidonic acid from membrane phospholipids.

The two biosynthetic pathways: cyclic & linear.

The cyclic pathway with the site of action of aspirin.

The reactions catalyzed by PGH2 synthase with two enzyme activities on the same protein: cyclooxygenase and peroxidase.

The X-ray structure of PGH2.

NSAID structures.

Aspirin acetylates ser 530 and blocks the cyclooxygenase activity.

The lipoxygenase-catalyzed oxidation of arachidonate to 5-HPETE.

The formation of leukotrienes.