Beneficial IFN-α treatment of tumorous herpes simplex blepharoconjunctivitis in dedicator of cytokinesis 8 deficiency Cihan Papan, MD, Beate Hagl, PhD,

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Presentation transcript:

Beneficial IFN-α treatment of tumorous herpes simplex blepharoconjunctivitis in dedicator of cytokinesis 8 deficiency Cihan Papan, MD, Beate Hagl, PhD, Valerie Heinz, MD, Michael H. Albert, MD, Oliver Ehrt, MD, Julie Sawalle-Belohradsky, Jens Neumann, MD, Martin Ries, MD, Philip Bufler, MD, Andreas Wollenberg, MD, Ellen D. Renner, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 5, Pages 1456-1458 (May 2014) DOI: 10.1016/j.jaci.2014.02.008 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Tumorous blepharoconjunctivitis before IFN-α therapy. Continuous improvement with residuae of the herpetic erosions visible 96 hours (B), 2 weeks (C), and 10 weeks (D) after the initiation of weekly IFN-α injections. E, Upper eyelid biopsy revealing epidermis with florid ulceration (hematoxylin and eosin, 1:100). F, Higher magnification (hematoxylin and eosin, 1:200) shows coagulative necrosis and cell debris (), granulation tissue in ulcer's base (), and regenerative changes of intact epithelium at margins of the lesion (). Journal of Allergy and Clinical Immunology 2014 133, 1456-1458DOI: (10.1016/j.jaci.2014.02.008) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Model of beneficial IFN-α effects on immunity in DOCK8 deficiency. B, B cell; CTL, cytotoxic T lymphocyte; NK, natural killer cell; STAT3, signal transducer and activator of transcription 3. Journal of Allergy and Clinical Immunology 2014 133, 1456-1458DOI: (10.1016/j.jaci.2014.02.008) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions