Ranitidine controls nocturnal gastric acid breakthrough on omeprazole: A controlled study in normal subjects Paolo L. Peghini, Philip O. Katz, Donald.

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Presentation transcript:

Ranitidine controls nocturnal gastric acid breakthrough on omeprazole: A controlled study in normal subjects Paolo L. Peghini, Philip O. Katz, Donald O. Castell Gastroenterology Volume 115, Issue 6, Pages 1335-1339 (December 1998) DOI: 10.1016/S0016-5085(98)70010-1 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Median intragastric (IG) pH values with 4 treatments in 12 subjects. The 4 treatments were placebo (Pla), 150 mg ranitidine (Ran 150), 300 mg ranitidine (Ran 300), and 20 mg omeprazole (Ome 20) at bedtime in addition to 20 mg omeprazole twice daily. Horizontal bars represent median values for the whole group. aP <0.001 vs. placebo and vs. omeprazole at bedtime; bP <0.005 vs. placebo. Gastroenterology 1998 115, 1335-1339DOI: (10.1016/S0016-5085(98)70010-1) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 2 Summary pH profile. Median hourly intragastric (IG) pH in 12 subjects receiving 4 treatments (Pla, placebo; Ran 150, 150 mg ranitidine; Ran 300, 300 mg ranitidine; Ome 20, 20 mg omeprazole) given at bedtime in addition to 20 mg of omeprazole twice daily. Gastroenterology 1998 115, 1335-1339DOI: (10.1016/S0016-5085(98)70010-1) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 3 Median percentage of time with intragastric pH <4 and <3 from intake of the study medication at 10:30 PM until end of the study at 6:30 AM. The 4 treatments were placebo (Pla), 150 mg ranitidine (Ran 150), 300 mg ranitidine (Ran 300), and 20 mg omeprazole (Ome 20) in addition to 20 mg omeprazole twice daily. *P < 0.005 vs. placebo, **P < 0.01 vs. omeprazole 20 for both pH 4 and pH 3. Gastroenterology 1998 115, 1335-1339DOI: (10.1016/S0016-5085(98)70010-1) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 4 Percentages of time with nocturnal intragastric (IG) pH <4 for the 4 treatments for each of the 12 subjects. The 4 treatments were placebo (Pla), 150 mg ranitidine (Ran 150), 300 mg ranitidine (Ran 300), and 20 mg omeprazole (Ome 20) given at bedtime in addition to 20 mg omeprazole twice daily. Gastroenterology 1998 115, 1335-1339DOI: (10.1016/S0016-5085(98)70010-1) Copyright © 1998 American Gastroenterological Association Terms and Conditions