The Health Economic Impact of Universal Infant Vaccination with the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine.

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Presentation transcript:

The Health Economic Impact of Universal Infant Vaccination with the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine as Compared with 13-Valent Pneumococcal Conjugate Vaccine in Hong Kong  Kenneth K.C. Lee, BSc (Pharm), MPhil, PhD, David Bin Chia Wu, PhD, Oleksandr Topachevskyi, BSc, Emmanuelle Delgleize, MSc, Rodrigo DeAntonio, MD, MSc  Value in Health Regional Issues  Volume 2, Issue 1, Pages 64-74 (May 2013) DOI: 10.1016/j.vhri.2013.01.012 Copyright © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 1 (A) Model structure. (B) Modeled age compartments and vaccine efficacy periods. AOM, acute otitis media; PCV-10, pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine; PCV-13, 13-valent pneumococcal conjugate vaccine. Value in Health Regional Issues 2013 2, 64-74DOI: (10.1016/j.vhri.2013.01.012) Copyright © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 2 One-way sensitivity analysis. AOM, acute otitis media; GP, general practitioner; HKD, Hong Kong dollars; IPD, invasive pneumococcal disease; NTHi, nontypeable Haemophilus influenzae; PCV-10, pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine; PCV-13, 13-valent pneumococcal conjugate vaccine; QALY, quality-adjusted life-year. Value in Health Regional Issues 2013 2, 64-74DOI: (10.1016/j.vhri.2013.01.012) Copyright © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 3 One-way scenario analysis. AOM, acute otitis media; GP, general practitioner; HKD, Hong Kong dollars; IPD, invasive pneumococcal disease; PCV-10, pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine; PCV-13, 13-valent pneumococcal conjugate vaccine; QALY, quality-adjusted life-year; VE, vaccine effectiveness. Value in Health Regional Issues 2013 2, 64-74DOI: (10.1016/j.vhri.2013.01.012) Copyright © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 4 Two-way scenario analysis. AOM, acute otitis media; GP, general practitioner; HKD, Hong Kong dollars; IPD, invasive pneumococcal disease; PCV-10, pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine; PCV-13, 13-valent pneumococcal conjugate vaccine; QALY, quality-adjusted life-year; VE, vaccine effectiveness. Value in Health Regional Issues 2013 2, 64-74DOI: (10.1016/j.vhri.2013.01.012) Copyright © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 5 Probabilistic sensitivity analysis PCV-10 versus PCV-13 in Hong Kong. WHO highly cost-effectiveness threshold for Hong Kong is less than GDP per capita (Hong Kong GDP per capita is HKD 266,026) [38,40]. GDP, gross domestic product; HKD, Hong Kong dollars; PCV-10, pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine; PCV-13, 13-valent pneumococcal conjugate vaccine; QALY, quality-adjusted life-year; WHO, World Health Organization. Value in Health Regional Issues 2013 2, 64-74DOI: (10.1016/j.vhri.2013.01.012) Copyright © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

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