Jeannette T. Bensen, MS, PhD, Director IHSFC jbensen@med.unc.edu UNC-Center for Environmental Health & Susceptibility Facilitate Research Training, Education, Community Engagement Susceptibility (CEHS) Translating interdisciplinary research on environmental health threats to improve public health in North Carolina. Integrated Health Sciences Facility Core Jeannette T. Bensen, MS, PhD, Director IHSFC jbensen@med.unc.edu

IHSFC Structure and Function PILOT PROJECTS PROGRAM & IAC SUBSEQUENT NIEHS APPLICATION THEME LEADERS ENVIRONMENTAL CANCER CARDIO - PULMONARY DISEASE DEVELOPMENTAL DISORDERS

Integrated Health Sciences Core Facility Specific Aims Jeannette Bensen, IHSFC Director Provide scientific consultation for clinical and translational human subjects studies. Assist with collection, processing, analysis, and storage of biospecimens. Facilitate access to collaborative human studies. RESEARCH CONTINUUM

Heavy Metal Well Water Contamination Geographically-based to Person-based CEHS investigator, Fry & Serre Members of COEC meet with state leaders at the NC-Division of Public Health to identify key concerns Historic well water data reported to 65,000 home owners CEHS scientists define slate belt and arsenic contamination in well water Next…evaluate exposure in individuals with health outcomes

IHSFC – Integration with COEC IHSFC brings together CEHS Environmental Scientists and COEC with Cancer Epidemiology Researchers and Resources CEHS investigator, Fry

IHSFC – Key accomplishments Baby Connectome Project Direct Assessment of Cognitive & Behavioral Development Parent Questionnaires Brain Imaging 4-6 MRIs 500 Typically Developing Children 0-5 years of age Followed 4 years Environmental Impacts on Early Brain Development *Link environmental toxicant exposures to longitudinal neuroimaging data *Collecting exposures and specimens CEHS Pilot Projects Program $$$ CEHS investigators, Piven, Lin, Engel

Integrated Health Sciences Offer Jeannette Bensen, IHSFC Director CEHS-affiliate medical center, UNC Health Care, to facilitate clinical translation Numerous, large, population-based and hospital-based case-control, case-only, and cohort studies Exposure assessment methodology and expertise (Mass Spec Core Facility) Advanced genomic capabilities (TCGA Site) Specialized animal models (Collaborative Cross) Health Registry Cancer Survivor Cohort

Integrated Health Sciences Ask Challenged with integrating large amounts of genomic data with exposure data (Big Data) Data sharing Data sharing demands Administratively taxing Requires infrastructure (tracking and secure transfer/websites) IRB, consent and data coding implications Date Use Agreements (DUA) Rarely this work is funded Streamline models for data sharing and collaboration Could IHSFC be the vehicle for integration and collaboration?