H. pylori GPS: Modulating Host Metabolites for Location Sensing

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H. pylori GPS: Modulating Host Metabolites for Location Sensing Daniela Keilberg, Karen M. Ottemann Cell Host & Microbe Volume 18, Issue 2, Pages 135-136 (August 2015) DOI: 10.1016/j.chom.2015.07.013 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Bacteria Can Sense Host Metabolites as Chemotaxis Ligands Host cells produce a wide range of metabolites that can be sensed by colonizing bacteria. Helicobacter pylori uses a mechanism to hydrolyze urea to CO2 and NH3. This reaction both helps to buffer the bacterium from harsh stomach acid and also lowers the amount of urea to a range that allows a chemotaxis response Cell Host & Microbe 2015 18, 135-136DOI: (10.1016/j.chom.2015.07.013) Copyright © 2015 Elsevier Inc. Terms and Conditions