Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens.

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Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens by Neus Masqué-Soler, Monika Szczepanowski, Christian W. Kohler, Rainer Spang, and Wolfram Klapper Blood Volume 122(11):1985-1986 September 12, 2013 ©2013 by American Society of Hematology

Digital multiplexed gene expression of mature aggressive B-cell lymphomas. Digital multiplexed gene expression of mature aggressive B-cell lymphomas. (A) Molecular classification of mature aggressive B-cell lymphomas as mBL, non-mBL, and intermediates using FFPE-derived RNA. The expression of the genes is color coded such that high expression is shown in yellow and low expression in blue. The molecular labels assigned by the array using fresh-frozen RNA and DMGE (nCounter) assay using FFPE-derived RNA are indicated as colored labels in the top bars. (B) Molecular classification of non-mBL using FFPE-derived RNA. The classification according to IHS (Hans), the array using fresh-frozen RNA and the DMGE assay using FFPE-derived RNA are indicated as colored labels in the top bars. Neus Masqué-Soler et al. Blood 2013;122:1985-1986 ©2013 by American Society of Hematology