Human Naive Embryonic Stem Cells: How Full Is the Glass?

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Human Naive Embryonic Stem Cells: How Full Is the Glass? Yixuan Wang, Shaorong Gao Cell Stem Cell Volume 18, Issue 3, Pages 301-303 (March 2016) DOI: 10.1016/j.stem.2016.02.012 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Derivation of Human Pluripotent Cells with Naive Properties Human naive pluripotent cells can be derived from individual ICM cells of pre-implantation embryos in the t2iLGöY condition, or from ICM or primed PSCs in the 5iLAF condition. The naive cells reverted from primed hESCs or derived from ICMs in 5iLAF, characterized by loss of SSEA4 expression, exhibit a methylation landscape with little similarities to that of the blastocyst as well as loss of imprinting. Cell Stem Cell 2016 18, 301-303DOI: (10.1016/j.stem.2016.02.012) Copyright © 2016 Elsevier Inc. Terms and Conditions