C. Sanchez, A. -C. Bay-Jensen, T. Pap, M. Dvir-Ginzberg, H

Slides:

Advertisements

Similar presentations

Page 1 What is TGF-β —Creative BioMart. Page 2 The transforming growth facor beta (TGF-β) superfamily is a large family of growth factors named after.

Advertisements

Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis.

Effects of exercise and weight loss on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the intensive.

The disease modifying osteoarthritis drug diacerein is able to antagonize pro inflammatory state of chondrocytes under mild mechanical stimuli B. Steinecker-Frohnwieser,

Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes Dr. T. Pufe, Ph.D., G. Groth, M.B. Goldring,

Volume 7, Issue 3, Pages (March 2005)

Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms Sarah J. Van Vickle-Chavez,

L. Pesesse, C. Sanchez, D. A. Walsh, J. -P. Delcour, C. Baudouin, P

Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes K.L.E.

The role of viruses in acute exacerbations of asthma

S. S. Pullamsetti, R. Savai, W. Janssen, B. K. Dahal, W. Seeger, F

Infrapatellar fat pad aggravates degeneration of acute traumatized cartilage: a possible role for interleukin-6 J. He, Y. Jiang, P.G. Alexander, V. Ulici,

NOD-like and Toll-like receptors or inflammasomes contribute to kidney disease in a canonical and a non-canonical manner Hans-Joachim Anders, Maciej.

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression.

Oral and topical boswellic acid attenuates mouse osteoarthritis

The epidemiology and impact of pain in osteoarthritis

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

Osteoarthritis pain mechanisms: basic studies in animal models

Macrophage heterogeneity, phenotypes, and roles in renal fibrosis

Aromatase is required for female abdominal aortic aneurysm protection

Figure 4 Macrophages in liver inflammation

Bone Morphogenetic Proteins and articular cartilage

Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors A. van Caam, W. Madej, E. Thijssen, A.

The Role of Tumor Stroma in Cancer Progression and Prognosis: Emphasis on Carcinoma-Associated Fibroblasts and Non-small Cell Lung Cancer Roy M. Bremnes,

C.-Y. Yang, A. Chanalaris, L. Troeberg Osteoarthritis and Cartilage

Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives Y. Henrotin Osteoarthritis and Cartilage

Inflammatory and immune cells involved in chronic obstructive pulmonary disease (COPD). Inflammatory and immune cells involved in chronic obstructive pulmonary.

Interleukin-1β and interleukin-6 disturb the antioxidant enzyme system in bovine chondrocytes: a possible explanation for oxidative stress generation

Activation of Adenylyl Cyclase Reduces TGF-β Profibrotic Response in Osteoarthritic Fibroblast-Like Synoviocytes M. Qadri, R. Ostrom, K.A. Elsaid Osteoarthritis.

Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked.

M.J. Martínez-Calatrava, R. Largo, G. Herrero-Beaumont

EGFR (Trans)activation Mediates IL-8 and Distinct Human Antimicrobial Peptide and Protein Production following Skin Injury Amanda S. Büchau Journal.

Volume 73, Issue 9, Pages (May 2008)

Pro-endometriotic niche in endometriosis

Osteoarthritis pain mechanisms: basic studies in animal models

Hepatic fibrosis: Concept to treatment

Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-β1 in ovariectomized rats S. Li, G. Niu, Y. Wu, G. Du,

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

J. Avouac, M.D., L. Gossec, M.D., M. Dougados, M.D.

Dr J. Deschner, D. M. D. , Ph. D. , Dr B. Rath-Deschner, D. M. D. , Ph

Volume 73, Issue 4, Pages (February 2008)

N.D. Miljkovic, M.D., Ph.D., G.M. Cooper, Ph.D., K.G. Marra, Ph.D.

Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium

J. Ranstam Osteoarthritis and Cartilage

Signal transduction in electrically stimulated articular chondrocytes involves translocation of extracellular calcium through voltage-gated channels

Role of TCF4 in signaling crosstalk with NFκB in human chondrocytes

Reciprocal functions of hepatocyte growth factor and transforming growth factor-β1 in the progression of renal diseases: A role for CD44? Sandrine Florquin,

Volume 76, Issue 4, Pages (August 2009)

Osteoarthritis and Cartilage

Biological actions of curcumin on articular chondrocytes

Osteopontin in diabetic nephropathy: signpost or road?

Who should have a joint replacement? A plea for more ‘phronesis’

Nitric oxide and vascular remodeling: Spotlight on the kidney

Bone Morphogenetic Proteins and articular cartilage

Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1β- stimulated chondrocytes – study in hypoxic alginate bead cultures

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

Effects of exercise and weight loss on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the intensive.

Novel juvenile factors for cartilage regeneration

B. Zielinska, M. Killian, M. Kadmiel, M. Nelsen, T.L. Haut Donahue

Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis

CD4+ T cells: a potential player in renal fibrosis

Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study L. Busija, R. Buchbinder, R.H. Osborne Osteoarthritis.

Osteoarthritis year 2012 in review: biology

Osteoarthritis and Cartilage

Coll2-1, Coll2-1NO2 and myeloperoxidase serum levels in erosive and non-erosive osteoarthritis of the hands L. Punzi, R. Ramonda, M. Deberg, P. Frallonardo,

The family of bone morphogenetic proteins

Claudia Loebel, Jason A. Burdick Cell Stem Cell

Osteoarthritis year in review 2016: mechanics

The chondrocyte primary cilium

General Information Osteoarthritis and Cartilage

Presentation transcript:

Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis C. Sanchez, A.-C. Bay-Jensen, T. Pap, M. Dvir-Ginzberg, H. Quasnichka, R. Barrett-Jolley, A. Mobasheri, Y. Henrotin Osteoarthritis and Cartilage Volume 25, Issue 8, Pages 1199-1209 (August 2017) DOI: 10.1016/j.joca.2017.02.797 Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Schematic representation of the chondrocyte secretome, based on data from mass-spectrometry based proteomic studies. ADAMTS: A Disintegrin And Metalloproteinase with Thrombospondin Motifs, Apo: apolipoprotein, BMP: Bone morphogenetic protein, CCL: Chemokine ligand, CHAD: Chondroadherin, ChM: chondromodulin, CILP: Cartilage intermediate layer protein, CHI3L1: Chitinase-3-like protein 1, COMP: Cartilage oligomeric matrix protein, CRLF: Cytokine receptor-like factor, CRTAC: Cartilage acidic protein, CSF: Macrophage colony-stimulating factor, CTGF: Connective tissue growth factor, Cx: connexin, CXCL: C-X-C motif chemokine ligand, ECM: extracellular matrix protein, ENPP: Ectonucleotide pyrophosphatase/phosphodiesterase family member, EMI: emilin, HSPA5: 78 kDa glucose-regulated protein, HTRA: High-temperature requirement A serine peptidase, IL: Interleukin, LTBP: Latent-transforming growth factor beta-binding protein, MGP: matrix gla protein, MMP: matrix metalloproteinase, PCOLCE: Procollagen C-endopeptidase enhancer, PLOD: Procollagen-lysine,2-oxoglutarate 5-dioxygenase, PRELP: proline-arginine-rich end leucine-rich repeat protein, SERPIN: serine protease inhibitors, SOD: superoxide dismutase, SPARC: Secreted protein acidic and rich in cysteine, TGFBI: Transforming growth factor-beta-induced protein ig-h3, TGF: transforming growth factor, TIMP: tissue inhibitor of metalloproteinase, TNAP: tissue non-specific alkaline phosphatase, TSP: thrombospondin. Osteoarthritis and Cartilage 2017 25, 1199-1209DOI: (10.1016/j.joca.2017.02.797) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions