Representative hematoxylin-eosin stained (HE) sections demonstrating immune checkpoint inhibition-related colitis representative HE sections demonstrating.

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Representative hematoxylin-eosin stained (HE) sections demonstrating immune checkpoint inhibition-related colitis representative HE sections demonstrating immune checkpoint inhibition-related colitis characterised by increased lamina propria cellularity (A, B and D). Representative hematoxylin-eosin stained (HE) sections demonstrating immune checkpoint inhibition-related colitis representative HE sections demonstrating immune checkpoint inhibition-related colitis characterised by increased lamina propria cellularity (A, B and D). (A) extension of the infiltrate into the submucosa. (B) neutrophilic inflammation with a crypt abscesses, mild cryptitis, mucin depletion of epithelial cells and small foci with minimal increase in intraepithelial lymphocytes. (C) Apoptotic cells in crypt epithelium. (D) Prominent intraepithelial lymphocytosis. Marnix H Geukes Foppen et al. ESMO Open 2018;3:e000278 Copyright © European Society for Medical Oncology. All rights reserved.