Epinephrine Evokes Renalase Secretion via a-Adrenoceptor/NF-κB Pathways in Renal Proximal Tubular Epithelial Cells Kidney Blood Press Res 2014;39:252-259.

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Epinephrine Evokes Renalase Secretion via a-Adrenoceptor/NF-κB Pathways in Renal Proximal Tubular Epithelial Cells Kidney Blood Press Res 2014;39:252-259 - DOI:10.1159/000355802 Fig. 1. Epinephrine induced renalase expression. Renalase protein levels increased significantly at 24 hr in the supernatants of HK2 cells incubated with three different concentrations of epinephrine (10-8, 10-7, 10-6 g/L) (vs control, P<0.01 respectively) (A and B). Renalase mRNA levels elevated at 6 hr, 12 hr and 24 hr with the stimulation of epinephrine (P<0.01 and P<0.05 respectively) (B). Levels of renalase mRNA presented a downward trend with the epinephrine's stimulation time (C and D) (n=6). Fig. 1E showed the time course of renalase secretion with epinephrine stimulation using Western blot (10-7 g/L, n=6). CTL, control; AD, epinephrine; *vs CTL, P<0.01; #vs CTL, P<0.05. © 2014 S. Karger AG, Basel - CC BY-NC 3.0

Epinephrine Evokes Renalase Secretion via a-Adrenoceptor/NF-κB Pathways in Renal Proximal Tubular Epithelial Cells Kidney Blood Press Res 2014;39:252-259 - DOI:10.1159/000355802 Fig. 2. Phentolamine attenuated epinephrine-evoked renalase expression. Epinephrine-induced (10-7g/L) renalase protein levels in the supernatants of HK2 cells were attenuated by phentolamine (1.0μmol/L) at 24 hr (vs control, P<0.01) (n=6) (A). Renalase mRNAs were reduced by pre-conditioned phentolamine (1.0μmol/L) (n=6, P<0.01) (B). CTL, control; AD, epinephrine; Phe, phentolamine; *vs CTL, P<0.01; #vs AD, P<0.05. © 2014 S. Karger AG, Basel - CC BY-NC 3.0

Epinephrine Evokes Renalase Secretion via a-Adrenoceptor/NF-κB Pathways in Renal Proximal Tubular Epithelial Cells Kidney Blood Press Res 2014;39:252-259 - DOI:10.1159/000355802 Fig. 3. TPCK supressed epinephrine-evoked renalase expression. Phospho-IκBα increased significantly in HK2 cells treated with epinephrine (10-7g/L) at 15 min (A) (n=6). Renalase mRNAs were attenuated by TPCK (45μmol/L) at 6 hr after treatment with epinephrine (P<0.05) (B) (n=6). CTL, control; TPCK, tosyl phenylalanyl chloromethyl ketone; AD, epinephrine; *vs CTL, P<0.01; #vs AD, P<0.05. © 2014 S. Karger AG, Basel - CC BY-NC 3.0