Antigen-Primed CD8+ T Cells Call DCs for Back Up

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Antigen-Primed CD8+ T Cells Call DCs for Back Up Marianne Burbage, Sebastian Amigorena  Immunity  Volume 46, Issue 2, Pages 163-164 (February 2017) DOI: 10.1016/j.immuni.2017.02.002 Copyright © 2017 Terms and Conditions

Figure 1 Activated CD8+ T Cells Recruit Two Types of DCs Upon viral infection, CD8+ T cells recognize viral peptides presented by infected DCs. Antigen-primed CD8+ T cells secrete MIP-1 (CCL3-CCL4 dimer) and XCL1, which recruit pDCs via CCR5 and XCR1+ DCs via XCR1, respectively. Local secretion of IFN-α by pDCs improves expression of costimulatory molecules by XCR1+ DCs, which in turn optimizes activation of CD8+ lymphocytes. Immunity 2017 46, 163-164DOI: (10.1016/j.immuni.2017.02.002) Copyright © 2017 Terms and Conditions

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