Volume 16, Issue 3, Pages (March 1996)

Slides:

Advertisements

Similar presentations

Jiang Wu, Bihua Bie, Hui Yang, Jijun J. Xu, David L

Advertisements

Volume 65, Issue 6, Pages (March 2010)

Polymodal Motion Processing in Posterior Parietal and Premotor Cortex

Volume 20, Issue 5, Pages (May 1998)

Elizabeth V. Goldfarb, Marvin M. Chun, Elizabeth A. Phelps Neuron

Volume 27, Issue 1, Pages (October 2013)

Volume 122, Issue 4, Pages (April 2002)

Molecular fMRI of Serotonin Transport

Volume 64, Issue 3, Pages (November 2009)

Volume 16, Issue 2, Pages (February 1996)

Spinal Cord Atrophy and Reorganization of Motoneuron Connections Following Long- Standing Limb Loss in Primates Carolyn W.-H. Wu, Jon H. Kaas Neuron

Volume 115, Issue 1, Pages (July 1998)

Volume 128, Issue 5, Pages (May 2005)

Dexmedetomidine-mediated neuroprotection against sevoflurane-induced neurotoxicity extends to several brain regions in neonatal rats J.F. Perez-Zoghbi,

Volume 37, Issue 2, Pages (January 2003)

Molecular Therapy - Methods & Clinical Development

The Well-Worn Route and the Path Less Traveled

Molecular Therapy - Nucleic Acids

Volume 65, Issue 1, Pages (January 2010)

Yukiyasu Kamitani, Frank Tong Current Biology

Volume 22, Issue 1, Pages (January 1999)

Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis P.I. Mapp, D.R. Sagar,

Volume 97, Issue 4, Pages e6 (February 2018)

Volume 22, Issue 4, Pages (January 2018)

Volume 38, Issue 5, Pages (June 2003)

Volume 23, Issue 1, Pages (April 2018)

Multiple Timescales of Memory in Lateral Habenula and Dopamine Neurons

Volume 45, Issue 4, Pages (February 2005)

Volume 54, Issue 2, Pages (April 2007)

Volume 16, Issue 4, Pages (February 2006)

Volume 25, Issue 12, Pages (December 2017)

Volume 90, Issue 3, Pages (May 2016)

Processing of Social and Monetary Rewards in the Human Striatum

Ryota Kanai, Tom Feilden, Colin Firth, Geraint Rees Current Biology

Volume 27, Issue 1, Pages (October 2013)

Volume 12, Issue 4, Pages (October 2005)

Volume 42, Issue 2, Pages (April 2004)

Volume 13, Issue 4, Pages (April 2011)

Targeting Dyrk1A with AAVshRNA Attenuates Motor Alterations in TgDyrk1A, a Mouse Model of Down Syndrome Jon Ortiz-Abalia, Ignasi Sahún, Xavier Altafaj,

Volume 8, Issue 2, Pages (February 2017)

Subliminal Instrumental Conditioning Demonstrated in the Human Brain

Volume 15, Issue 1, Pages (January 2007)

Strong Promoters Are the Key to Highly Efficient, Noninflammatory and Noncytotoxic Adenoviral-Mediated Transgene Delivery into the Brain in Vivo Christian.

Elena A. Allen, Erik B. Erhardt, Vince D. Calhoun Neuron

Daniel E. Winkowski, Eric I. Knudsen Neuron

Volume 97, Issue 6, Pages e5 (March 2018)

Organization of Functional Long-Range Circuits Controlling the Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus Li Zhou, Ming-Zhe Liu, Qing.

Arielle Tambini, Nicholas Ketz, Lila Davachi Neuron

John T. Serences, Geoffrey M. Boynton Neuron

Flies by Night Current Biology

Volume 90, Issue 3, Pages (August 1997)

Volume 66, Issue 6, Pages (June 2010)

Kasey L Jackson, Robert D Dayton, Ronald L Klein

The Kv4.2 Potassium Channel Subunit Is Required for Pain Plasticity

Volume 90, Issue 3, Pages (May 2016)

Volume 2, Issue 3, Pages (March 2014)

Functional magnetic stimulation facilitates colonic transit in rats

Antegrade cerebral perfusion reduces apoptotic neuronal injury in a neonatal piglet model of cardiopulmonary bypass Valerie Y. Chock, MD, Gabriel Amir,

Volume 21, Issue 12, Pages (December 2013)

TrkA Activation Is Sufficient to Rescue Axotomized Cholinergic Neurons

Volume 17, Issue 18, Pages (September 2007)

ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. (A,B)

Network-Level Changes in Expression of Inducible Fos–Jun Proteins in the Striatum during Chronic Cocaine Treatment and Withdrawal Rosario Moratalla,

Volume 34, Issue 4, Pages (May 2002)

Multisensory Integration in the Mouse Striatum

Volume 12, Issue 23, Pages (December 2002)

Volume 10, Issue 1, Pages (July 2004)

Volume 13, Issue 1, Pages (January 2006)

Molecular Therapy - Methods & Clinical Development

Vomeronasal Phenotype and Behavioral Alterations in Gαi2 Mutant Mice

Presentation transcript:

Volume 16, Issue 3, Pages 665-673 (March 1996) GDNF Induces a Dystonia-like State in Neonatal Rats and Stimulates Dopamine and Serotonin Synthesis Klaus D Beck, Ian Irwin, Janet Valverde, Thomas J Brennan, J.William Langston, Franz Hefti Neuron Volume 16, Issue 3, Pages 665-673 (March 1996) DOI: 10.1016/S0896-6273(00)80085-9

Figure 1 Increased Muscle Tonus Following Intrastriatal Injection of GDNF Shown are rat pups at P8 that had received bilateral intrastriatal injections of GDNF at P2. (A) Comparison to a cytochrome C injected littermate (bottom). Note reduced body size and hyperflexed forelimbs in GDNF injected pup. (B) When lifted up, GDNF injected pups do not extend their forelimbs. (C–G) Tails of cytochrome C injected pups are smoothly curved (C), while GDNF injected rats show multiple kinks and toes are kept in a clawed position (D). Close up of forelimbs show normal positioning (E) and hyperflexion after GDNF injection (F); forelimbs were kept in this position during all activities. Unilateral striatal GDNF injections induce contralateral forelimb hyperflexion (G). Neuron 1996 16, 665-673DOI: (10.1016/S0896-6273(00)80085-9)

Figure 2 Postnatal Increase in Body and Brain Weights Data for body (A) or brain (B) weights from control rats (closed bars) and from rats following injection of GDNF (dotted bars) or cytochrome C (hatched bars). Asterisks indicate statistically significant differences from corresponding control and cytochrome C groups (one asterisk, p < 0.05; two asterisks, p < 0.01; Student's t test). Neuron 1996 16, 665-673DOI: (10.1016/S0896-6273(00)80085-9)

Figure 3 GDNF Dose-Response Analysis DA (A) and 5-HT (B) levels in P8 rats after bilateral striatal injection of GDNF. Equal volumes of GDNF dilutions were injected at P2, and DA/5-HT levels were determined in P8 striata and ventral mesencephali as described in Experimental Procedures. Asterisks indicate statistically significant differences from corresponding control and cytochrome C groups (one asterisk, p < 0.05; two asterisks, p < 0.01; Student's t test). P8 rats injected with 0.05 μg GDNF did not show any behavioral changes, those injected with 0.5 μg displayed slight paw clawing and tail kinking, but no forelimb hyperflexion. The group injected with 5 μg GDNF showed the full dystonia-like pattern seen after 10 μg GDNF. Neuron 1996 16, 665-673DOI: (10.1016/S0896-6273(00)80085-9)

Figure 4 TH Immunostaining Coronal brain sections at corresponding levels of striatum (A and C) and mesencephalon (B and D) of P8 rats following injection of cytochrome C (A and B) or GDNF (C and D). Pattern and intensity of TH staining is not significantly different; there was no aberrant TH staining throughout the brain. Neuron 1996 16, 665-673DOI: (10.1016/S0896-6273(00)80085-9)