Announcements as of 3 December 2008 Last Week of Class & Lab Renal physiology lectures GI Physiology lecture Urinalysis lab Sign up for Exam Day Moeller’s section Monday 9am Davis’s section Friday 9am Notify & commit no later than Friday of this week! Exam Week Take exam on Monday or Friday Revised Abstracts due no later than 9:00 Friday Optional (but highly recommended) Meet with professor during exam week for feedback before revising abstract.

Figure 14.27 Apply this information to each of the three Test Beverages used in the Urinalysis Lab!

Figure 14.30 Apply this information to each of the three Test Beverages used in the Urinalysis Lab! Cell in the adrenal cortex that respond to AII are also receptors for plasma K+ concentration. Sodium reabsorption and potassium secretion are coupled.

Under hormonal control by Aldosterone! Figure 14.14 Under hormonal control by Aldosterone! Sodium reabsorption and potassium secretion are coupled.

Lung-kidney connection Acid-Base Balance

Normally, all filtered bicarbonate is “reabsorbed” Figure 14.31 Normally, all filtered bicarbonate is “reabsorbed”

This process is increased during metabolic acidosis Figure 14.32 This process is increased during metabolic acidosis Excess H+ eliminated in urine bound to phosphate buffer.

This process is increased during metabolic acidosis Figure 14.33 Filtration Reabsorption Secretion Metabolism Metabolism of glutamine in tubular cells generate bicarbonate buffer. This process is increased during metabolic acidosis

Father-in-law with emphysema (respiratory case studies lab) PaCO2 =30 mmHg, plasma pH = 7.47 Hyperventilating: ventilation in excess of metabolism to compensate for loss of alveolar surface area for diffusion of O2 Commensurate loss of CO2 RESPIRATORY ALKALOSIS Renal compensation……… retain H+ and eliminate HCO3- Review 3 previous slides.

For exam: understand the ventilatory compensation for Table 14.08 For exam: understand the ventilatory compensation for Metabolic acidosis as a result of diarrhea and Metabolic alkalosis as a result of vomiting.

Table 14.07

Table 14.06