Cord-Blood Hematopoietic Stem Cell Transplant Confers an Increased Risk for Human Herpesvirus-6-Associated Acute Limbic Encephalitis: A Cohort Analysis

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Presentation transcript:

Cord-Blood Hematopoietic Stem Cell Transplant Confers an Increased Risk for Human Herpesvirus-6-Associated Acute Limbic Encephalitis: A Cohort Analysis Joshua A. Hill, Sophia Koo, Belisa B. Guzman Suarez, Vincent T. Ho, Corey Cutler, John Koreth, Philippe Armand, Edwin P. Alyea, Lindsey R. Baden, Joseph H. Antin, Robert J. Soiffer, Francisco M. Marty Biology of Blood and Marrow Transplantation Volume 18, Issue 11, Pages 1638-1648 (November 2012) DOI: 10.1016/j.bbmt.2012.04.016 Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 This figure demonstrates brain axial fluid attenuation inversion recovery (FLAIR) magnetic resonance images (MRIs) from 2 patients with human herpesvirus-6 posttransplantation acute limbic encephalitis. (A) MRI from the recipient of an adult-donor hematopoietic stem cell transplantation showing characteristic well-demarcated, high-intensity signal abnormalities in the bilateral medial temporal lobes involving the hippocampus and amygdala. (B) MRI from the recipient of an umbilical cord blood transplantation showing signal abnormalities extending beyond the limbic system. Biology of Blood and Marrow Transplantation 2012 18, 1638-1648DOI: (10.1016/j.bbmt.2012.04.016) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Receiver-operating characteristic (ROC) curves plotting the sensitivity and specificity of peak plasma human herpesvirus-6 (HHV-6) viral loads for the development of posttransplantation acute limbic encephalitis (HHV-6-PALE). (A) Two hundred ten patients in the entire cohort had plasma HHV-6 testing, and 92 were positive. (B) Sixty-eight patients in the umbilical cord blood transplantation (UCBT) cohort had plasma HHV-6 testing, and 49 were positive. Biology of Blood and Marrow Transplantation 2012 18, 1638-1648DOI: (10.1016/j.bbmt.2012.04.016) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions