Vibrio cholerae Short, curved, rod-shaped with single polar flagellum

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Vibrio cholerae Short, curved, rod-shaped with single polar flagellum M. Brunn F2013 Modified by DYH Short, curved, rod-shaped with single polar flagellum Gram-negative Possesses 2 circular chromosomes ~4 million base pairs 3,885 predicted genes Reside in people and aquatic sources Causes cholera Infection of the small intestine http://en.wikipedia.org/wiki/Vibrio_cholerae

Vibrio cholerae Cholera toxin is released from V. cholerae M. Brunn F2013 Modified by DYH Vibrio cholerae Cholera toxin is released from V. cholerae Binds to enterocytes Triggers endocytosis of the toxin Activates G-protein in the cytosol ADP-ribosylation locks G-protein in GTP form which continually stimulates production of cAMP High levels of cAMP activate the cystic fibrosis transmembrane conductance regulator (CFTR) http://www.ebi.ac.uk/interpro/potm/2005_9/Page2.htm