Percutaneous coronary invervention versus coronary artery bypass grafting: A meta- analysis Yolba Smit, MD, MSc, Joan Vlayen, MD, Hetty Koppenaal, MD,

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Percutaneous coronary invervention versus coronary artery bypass grafting: A meta- analysis Yolba Smit, MD, MSc, Joan Vlayen, MD, Hetty Koppenaal, MD, MPH, Frank Eefting, MD, Arie Pieter Kappetein, MD, PhD, Massimo A. Mariani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 149, Issue 3, Pages 831-838.e13 (March 2015) DOI: 10.1016/j.jtcvs.2014.10.112 Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Meta-analysed odds ratio for death after PCI or CABG at the latest available follow-up. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Flow diagram of the search and selection process. RCT, Randomized controlled trial. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 Meta-analyzed odds ratios for death after PCI or CABG at the latest available follow-up. PCI, Percutaneous coronary intervention; CABG, coronary artery bypass grafting; CI, confidence interval; AMIST, Angioplasty versus Minimally Invasive Surgery Trial; ARTS, Arterial Revascularization Therapies Study; BARI, Bypass Angioplasty Revascularization Investigation; CABRI, Coronary Angioplasty versus Bypass Revascularisation Investigation; EAST, Emory Angioplasty versus Surgery Trial; ERACI I, Argentine Randomized Trial of Percutaneous Transluminal Coronary Angioplasty Versus Coronary Artery Bypass Surgery in Multivessel Disease; GABI, German Angioplasty Bypass Surgery Investigation; MASS, Medicine, Angioplasty, or Surgery Study; RITA, Randomised Intervention Treatment of Angina; ERACI II, Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients with Multiple Vessel Disease; SIMA, Stenting versus Internal Mammary Artery grafting trial; SoS, Stent or Surgery Trial; CARDia, Coronary Artery Revascularization in Diabetes; FREEDOM, Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease; PRECOMBAT, Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease; SYNTAX, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E3 Meta-analyzed odds ratios for myocardial infarction after PCI or CABG at the latest available follow-up. PCI, Percutaneous coronary intervention; CABG, coronary artery bypass grafting; CI, confidence interval; MI, myocardial infarction; AMIST, Angioplasty versus Minimally Invasive Surgery Trial; ARTS, Arterial Revascularization Therapies Study; CABRI, Coronary Angioplasty versus Bypass Revascularisation Investigation; EAST, Emory Angioplasty versus Surgery Trial; ERACI I, Argentine Randomized Trial of Percutaneous Transluminal Coronary Angioplasty Versus Coronary Artery Bypass Surgery in Multivessel Disease; GABI, German Angioplasty Bypass Surgery Investigation; MASS, Medicine, Angioplasty, or Surgery Study; RITA, Randomised Intervention Treatment of Angina; ERACI II, Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients with Multiple Vessel Disease; SIMA, Stenting versus Internal Mammary Artery grafting trial; SoS, Stent or Surgery Trial; CARDia, Coronary Artery Revascularization in Diabetes; FREEDOM, Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease; PRECOMBAT, Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease; SYNTAX, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E4 Meta-analyzed odds ratios for repeat revascularization after PCI or CABG at the latest available follow-up. PCI, Percutaneous coronary intervention; CABG, coronary artery bypass grafting; CI, confidence interval; RR, repeat revascularization; TVR, target vessel revascularization; AMIST, Angioplasty versus Minimally Invasive Surgery Trial; ARTS, Arterial Revascularization Therapies Study; BARI, Bypass Angioplasty Revascularization Investigation; CABRI, Coronary Angioplasty versus Bypass Revascularisation Investigation; EAST, Emory Angioplasty versus Surgery Trial; ERACI I, Argentine Randomized Trial of Percutaneous Transluminal Coronary Angioplasty Versus Coronary Artery Bypass Surgery in Multivessel Disease; GABI, German Angioplasty Bypass Surgery Investigation; MASS, Medicine, Angioplasty, or Surgery Study; RITA, Randomised Intervention Treatment of Angina; ERACI II, Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients with Multiple Vessel Disease; SIMA, Stenting versus Internal Mammary Artery grafting trial; SoS, Stent or Surgery Trial; CARDia, Coronary Artery Revascularization in Diabetes; FREEDOM, Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease; PRECOMBAT, Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease; SYNTAX, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E5 Meta-analyzed odds ratios for stroke after PCI or CABG at the latest available follow-up. PCI, Percutaneous coronary intervention; CABG, coronary artery bypass grafting; CI, confidence interval; ARTS, Arterial Revascularization Therapies Study; CARDia, Coronary Artery Revascularization in Diabetes; FREEDOM, Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease; MASS, Medicine, Angioplasty, or Surgery Study; PRECOMBAT, Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease; SYNTAX, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E6 Meta-analyzed odds ratios for cardiac death after PCI or CABG at the latest available follow-up. PCI, Percutaneous coronary intervention; CABG, coronary artery bypass grafting; CI, confidence interval; BARI, Bypass Angioplasty Revascularization Investigation; ERACI I, Argentine Randomized Trial of Percutaneous Transluminal Coronary Angioplasty Versus Coronary Artery Bypass Surgery in Multivessel Disease; ERACI II, Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients with Multiple Vessel Disease; MASS, Medicine, Angioplasty, or Surgery Study; PRECOMBAT, Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease; RITA, Randomised Intervention Treatment of Angina; SIMA, Stenting versus Internal Mammary Artery grafting trial; SoS, Stent or Surgery Trial; SYNTAX, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E7 Meta-analyzed odds ratios for angina-free survival after PCI or CABG at the latest available follow-up. PCI, Percutaneous coronary intervention; CABG, coronary artery bypass grafting; AFS, angina-free survival; CI, confidence interval; AMIST, Angioplasty versus Minimally Invasive Surgery Trial; ARTS, Arterial Revascularization Therapies Study; CABRI, Coronary Angioplasty versus Bypass Revascularisation Investigation; ERACI I, Argentine Randomized Trial of Percutaneous Transluminal Coronary Angioplasty Versus Coronary Artery Bypass Surgery in Multivessel Disease; ERACI II, Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients with Multiple Vessel Disease; FREEDOM, Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease; GABI, German Angioplasty Bypass Surgery Investigation; MASS, Medicine, Angioplasty, or Surgery Study; SoS, Stent or Surgery Trial. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E8 Meta-analyzed odds ratios for death per time period of follow-up, PCI versus CABG. OR, Odds ratio; n, number of studies meta-analyzed; y, years of follow-up. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E9 Meta-analyzed odds ratios for myocardial infarction per time period of follow-up, PCI versus CABG. OR, Odds ratio; n, number of studies meta-analyzed; y, years of follow-up. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E10 Meta-analyzed odds ratios for repeat revascularization per time period of follow-up, PCI versus CABG. OR, Odds ratio; n, number of studies meta-analyzed; y, years of follow-up. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E11 Meta-analyzed odds ratios for stroke per time period of follow-up, PCI versus CABG. OR, Odds ratio; n, number of studies meta-analyzed; y, years of follow-up. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 831-838.e13DOI: (10.1016/j.jtcvs.2014.10.112) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions