Paul M. George, Gary K. Steinberg Neuron

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Presentation transcript:

Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments Paul M. George, Gary K. Steinberg Neuron Volume 87, Issue 2, Pages 297-309 (July 2015) DOI: 10.1016/j.neuron.2015.05.041 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Pathophysiology of Stroke Neuron 2015 87, 297-309DOI: (10.1016/j.neuron.2015.05.041) Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 2 Temporal Profile of Changes Induced by Neural Stem Cell Enhanced Stroke Recovery This figure was courtesy of Horie et al., 2011. Neurological behavior indicates motor recovery. The asterisk indicates that Avastin affected all parameters except for the ones marked; two asterisks indicate the inconclusive effects of Avastin. BBB, blood-brain barrier; βDG, β-dystroglycan; BVD, blood vessel density; Iba-1, ionized calcium binding adaptor molecule 1; Tie-2, a receptor tyrosine kinase; VEGF, vascular endothelial growth factor. Neuron 2015 87, 297-309DOI: (10.1016/j.neuron.2015.05.041) Copyright © 2015 Elsevier Inc. Terms and Conditions