Geoffrey K. Mitchell, PhD, FRACGP, FAChPM, Janet R

Slides:

Advertisements

Similar presentations

Comparison of the Constipation Assessment Scale and Plain Abdominal Radiography in the Assessment of Constipation in Advanced Cancer Patients Kittiphon.

Advertisements

David C. Currow, MPH, FRACP, John L

Transcutaneous Electrical Nerve Stimulation vs

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Palliative Caregivers Who Would Not Take on the Caring Role Again

Neurotoxicity from Chronic Opioid Therapy After Successful Palliative Treatment for Painful Bone Metastases Andrew Broadbent, BMedSc, MBChB, FRACP, FAChPM,

Once-Daily Opioids for Chronic Dyspnea: A Dose Increment and Pharmacovigilance Study David C. Currow, BMed, MPH, FRACP, Christine McDonald, MBBS, PhD,

A Randomized, Double-Blind, Crossover Trial of the Effect of Oxygen on Dyspnea in Patients with Advanced Cancer Jennifer Philip, MBBS, MMed, Dip Pall.

Advancing Palliative Care as a Human Right

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Transcutaneous Electrical Nerve Stimulation vs

Is the Life Space Assessment Applicable to a Palliative Care Population? Its Relationship to Measures of Performance and Quality of Life Jane Louise.

The Relationship Between Two Performance Scales: New York Heart Association Classification and Karnofsky Performance Status Scale Miriam J. Johnson,

A Systematic Review of Prognostic/End-of-Life Communication with Adults in the Advanced Stages of a Life-Limiting Illness: Patient/Caregiver Preferences.

A Framework for Generalizability in Palliative Care

Why Now? Timing and Circumstances of Hastened Deaths

Katherine Clark, MB, BS, MMed, FRACP, FAChPM, David C

A Social Capital Framework for Palliative Care: Supporting Health and Well-Being for People With Life-Limiting Illness and Their Carers Through Social.

Do the Trajectories of Dyspnea Differ in Prevalence and Intensity By Diagnosis at the End of Life? A Consecutive Cohort Study David C. Currow, BMed,

Is the Life Space Assessment Applicable to a Palliative Care Population? Its Relationship to Measures of Performance and Quality of Life Jane Louise.

Efficacy of Dexmethylphenidate for the Treatment of Fatigue After Cancer Chemotherapy: A Randomized Clinical Trial Elyse E. Lower, MD, Stewart Fleishman,

Fatigue in Gynecological Cancer Patients During and After Anticancer Treatment Gillian Prue, PhD, James Allen, PhD, Jacqueline Gracey, PhD, Jane Rankin,

Improving Outcomes for People With Progressive Cancer: Interrupted Time Series Trial of a Needs Assessment Intervention Amy Waller, PhD, Afaf Girgis,

Facilitating Needs-Based Support and Palliative Care for People With Chronic Heart Failure: Preliminary Evidence for the Acceptability, Inter-Rater Reliability,

What Influences Patients’ Decisions on Artificial Hydration at the End of Life? A Q- Methodology Study Catherine Malia, MSc, Michael I. Bennett, MB, ChB,

Arif H. Kamal, MD, David C. Currow, BMed, MPH, Christine S

Double-Blind, Placebo-Controlled, Randomized Trial of Octreotide in Malignant Bowel Obstruction David C. Currow, FRACP, Stephen Quinn, PhD, Meera Agar,

An Assessment of the Screening Performance of a Single-Item Measure of Depression From the Edmonton Symptom Assessment Scale Among Chronically Ill Hospitalized.

Double-Blind, Placebo-Controlled Trial of Lamotrigine in Combination with Other Medications for Neuropathic Pain Marianne Silver, MS, David Blum, MD,

Self-Reported Constipation in Patients With Advanced Cancer: A Preliminary Report Wadih Rhondali, MD, Linh Nguyen, MD, Lynn Palmer, PhD, Duck-Hee Kang,

Bruce H. Chamberlain, MD, Karen Cross, MD, Jaron L

Delivery Strategies to Optimize Resource Utilization and Performance Status for Patients With Advanced Life-Limiting Illness: Results From the “Palliative.

The Experience of Cancer-Related Fatigue and Chronic Fatigue Syndrome: A Qualitative and Comparative Study Barbara Bennett, RN, BSc, PhD, David Goldstein,

Susan E. Hardy, MD, PhD, Stephanie A. Studenski, MD, MPH

Prevalence of Sudden Death in Palliative Care: Data From the Australian Palliative Care Outcomes Collaboration Magnus Ekström, MD, PhD, Maxwell T. Vergo,

Development of a Brief Survey to Measure Nursing Home Residents' Perceptions of Pain Management Joan M. Teno, MD, MS, David Dosa, MD, MPH, Therese Rochon,

Age-Associated Differences in Fatigue Among Patients with Cancer

David Clark, PhD, Michael Wright, PhD

Redefining Appropriate Treatment Expectations

Clinical Response to an Outpatient Palliative Care Consultation in Patients With Advanced Cancer and Cancer Pain Sriram Yennurajalingam, MD, Jung Hun.

Skye Tian Dong, BPsych (Hons), Phyllis N. Butow, PhD, Daniel S. J

Lack of Benefit From Paracetamol (Acetaminophen) for Palliative Cancer Patients Requiring High-Dose Strong Opioids: A Randomized, Double-Blind, Placebo-Controlled,

Changes in Symptom Intensity Among Cancer Patients Receiving Outpatient Palliative Care Jung Hun Kang, MD, PhD, Jung Hye Kwon, MD, PhD, David Hui, MD,

Transcutaneous Electrical Nerve Stimulation vs

Comparison of Fatigue, Pain, and Depression in Patients With Advanced Kidney Disease and Cancer—Symptom Burden and Clusters Manisha Jhamb, MD, MPH, Khaled.

Ecological Momentary Assessment of Fatigue in Patients Receiving Intensive Cancer Therapy Eileen Danaher Hacker, PhD, APN, AOCN, Carol Estwing Ferrans,

Letter to the Editor Re: “Hyoscine Butylbromide for the Management of Death Rattle: Sooner Rather Than Later” Katherine Clark, MBBS, MMed, PhD, FRACP,

Amitriptyline in the Treatment of Chemotherapy-Induced Neuropathic Symptoms Anna-Liisa Kautio, MD, Maija Haanpää, MD, PhD, Tiina Saarto, MD, PhD, Eija.

Barrie R. Cassileth, PhD, Andrew J. Vickers, PhD

Susan C. Miller, PhD, Dan K. Kiely, MPH, MA, Joan M

The Pro-Self© Pain Control Program Improves Patients' Knowledge of Cancer Pain Management Tone Rustøen, RN, PhD, Berit Taraldsen Valeberg, RN, PhD, Eva.

Robyn M. Keall, RN, MS, PhD (C), Josephine M

Armodafinil for Sarcoidosis-Associated Fatigue: A Double-Blind, Placebo-Controlled, Crossover Trial Elyse E. Lower, MD, Atul Malhotra, MD, Victoria Surdulescu,

Development and Reliability Testing of the Victoria Bowel Performance Scale (BPS) G. Michael Downing, MD, Craig Kuziemsky, PhD, Mary Lesperance, PhD,

David C. Currow, MPH, FRACP, John L

Association Between Symptom Distress and Survival in Outpatients Seen in a Palliative Care Cancer Center J. Lynn Palmer, PhD, Michael J. Fisch, MD, MPH

Margot E. Kurtz, PhD, Jay C. Kurtz, PhD, Charles W

Validation of a Fentanyl Transdermal Adhesion Scoring Tool for Use in Clinical Practice Sudeep Raj Bista, BPharm, MSPharm, MMedRes, Janet Hardy, BSc,

Hospice Care for Heart Failure Patients

The Efficacy of Haloperidol in the Management of Nausea and Vomiting in Patients with Cancer Janet R. Hardy, BSc, MD, FRACP, FAChPM, Angela O'Shea, BNurs,

David C. Currow, MPH, FRACP, John L

Physical Function in Patients with Cancer

Development of a Brief Survey to Measure Nursing Home Residents' Perceptions of Pain Management Joan M. Teno, MD, MS, David Dosa, MD, MPH, Therese Rochon,

Palliative Caregivers Who Would Not Take on the Caring Role Again

Kari R. Hexem, MPH, Victoria A. Miller, PhD, Karen W

Fatigue in Patients with Cancers of the Breast or Prostate Undergoing Radical Radiotherapy Patrick Stone, MA, MD, MRCP, Michael Richards, MA, MD, MRCP,

Helping Patients with Advanced Cancer Live with Concerns About Eating: A Challenge for Palliative Care Professionals Jane Hopkinson, PhD, RGN, Jessica.

The Association of Depression and Pain with Health-Related Quality of Life, Disability, and Health Care Use in Cancer Patients Kurt Kroenke, MD, Dale.

Fatigue in Gynecological Cancer Patients During and After Anticancer Treatment Gillian Prue, PhD, James Allen, PhD, Jacqueline Gracey, PhD, Jane Rankin,

Patient-Controlled Analgesia for Children at Home

Presentation transcript:

The Effect of Methylphenidate on Fatigue in Advanced Cancer: An Aggregated N-of-1 Trial Geoffrey K. Mitchell, PhD, FRACGP, FAChPM, Janet R. Hardy, MD, FRACP, Catherine J. Nikles, MBBS, PhD, Sue-Ann S. Carmont, BA(Hons), Hugh E. Senior, PhD, Philip J. Schluter, PhD, Phillip Good, PhD, FRACP, David C. Currow, FRACP, MPH Journal of Pain and Symptom Management Volume 50, Issue 3, Pages 289-296 (September 2015) DOI: 10.1016/j.jpainsymman.2015.03.009 Copyright © 2015 Terms and Conditions

Fig. 1 Typical N-of-1 study. The order of treatment and placebo are randomly assigned for each cycle. Journal of Pain and Symptom Management 2015 50, 289-296DOI: (10.1016/j.jpainsymman.2015.03.009) Copyright © 2015 Terms and Conditions

Fig. 2 Patient flowchart, showing timing of, and reasons for, withdrawal. Journal of Pain and Symptom Management 2015 50, 289-296DOI: (10.1016/j.jpainsymman.2015.03.009) Copyright © 2015 Terms and Conditions

Fig. 3 a) Mean difference (95% credible intervals [CIs]) between methylphenidate (MPH) compared with placebo on individual fatigue scores (Functional Assessment of Chronic Illness Therapy-Fatigue [FACIT-F]) for each patient (circle) and the overall group (square). b) Mean difference (95% CIs) between MPH compared with placebo on individual Wu Cancer Fatigue Scale scores for each patient (circle) and the overall group (square). c) Mean difference (95% CIs) between MPH compared with placebo on individual Edinburgh Depression Scale scores for each patient (circle) and the overall group (square). a–c) Note: the solid black circles designate positive responders, the hollow circles designate nonresponders, and the solid gray circle designates a negative responder. Journal of Pain and Symptom Management 2015 50, 289-296DOI: (10.1016/j.jpainsymman.2015.03.009) Copyright © 2015 Terms and Conditions