Interaction between the anti-EGFR Goldbody and sEGFR at the molecular level. Interaction between the anti-EGFR Goldbody and sEGFR at the molecular level.

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Interaction between the anti-EGFR Goldbody and sEGFR at the molecular level. Interaction between the anti-EGFR Goldbody and sEGFR at the molecular level. (A) Binding of AuNPs functionalized with different numbers of Pep2 onto immobilized sEGFR. (B) Binding of AuNP–Pep2 (red), AuNP–Pep2s (green), AuNP–Pep2m (blue), and free Pep2 (cyan) onto immobilized sEGFR, EGF, and BSA. (C) SPR kinetics of the interaction between AuNP–Pep2 and immobilized sEGFR. Red curves are the fitting lines (see SI Appendix, Fig. S8B for the residue plot). (D) SPR kinetics of the interaction between EGF and immobilized sEGFR. Red curves are the fitting lines (see SI Appendix, Fig. S8C for the residue plot). (E) Binding of sEGFR onto immobilized EGF in the absence (red) or the presence of AuNP–Pep2 (green), AuNP–Pep2s (blue), free Pep2 (cyan), or free Pep2s (magenta). (F) TEM image of the 1:1 complex of anti-EGFR Goldbody (dark balls) and sEGFR. Error bars indicate SDs. RU, resonance unit. Gui-Hua Yan et al. PNAS 2018;115:1:E34-E43 ©2018 by National Academy of Sciences