UNDERSTANDING RISK STRATIFICATION IN PAH:
PAH Burden of Disease
The Rationale for Evaluation of PAH Severity
ESC/ERS Pulmonary Hypertension Guidelines: Parameters of a Comprehensive Risk Assessment
Comprehensive Prognostic Evaluation and Risk Assessment
PAH Expert Referral Centers
Definition of Patient Status
Classification of WHO Group 1 (PAH)
Components of a Comprehensive Risk Assessment
Suggested Assessment and Timing for Follow-Up of Patients with PAH
Case 1: 45-Year-Old Woman With Idiopathic PAH Before Starting Treatment
Case 1: 45-Year-Old Woman With Idiopathic PAH Before Starting Treatment (cont)
Evidence-Based Treatment Algorithm for Patients With PAH
Case 1: 45-Year-Old Woman With Idiopathic PAH After 4 Months of Treatment With Initial Oral Combination Therapy (PDE5 Inhibitor + ERA)
Case 1: 45-Year-Old Woman With Idiopathic PAH After 4 Months of Treatment With Initial Oral Combination Therapy (PDE5 Inhibitor + ERA) (cont)
Case 1: 45-Year-Old Woman With Idiopathic PAH After 4 Months of Treatment With Initial Oral Combination Therapy (PDE5 Inhibitor + ERA) (cont)
Evidence-Based Treatment Algorithm for Patients With PAH
ESC/ERS Recommendations for Sequential Drug Combination Therapy for PAH
Case 2: 34-Year-Old Man With Idiopathic PAH: Syncope and Breathlessness for 2 Years at Baseline
Case 2: 34-Year-Old Man With Idiopathic PAH: Syncope and Breathlessness for 2 Years at Baseline (cont)
Case 2: 34-Year-Old Man With Idiopathic PAH After 4 Months of Combination Therapy With Intravenous Epoprostenol
Case 2: 34-Year-Old Man With Idiopathic PAH After 4 Months of Combination Therapy With Intravenous Epoprostenol (cont)
Case 3: 64-Year-Old Woman With Scleroderma-Associated PAH at Baseline
Case 3: 64-Year-Old Woman With Scleroderma-Associated PAH at Baseline (cont)
AMBITION: Initial Combination Therapy Improves Patient Outcomes vs Monotherapy in FC II Patients With PAH
Conclusions
Abbreviations
Abbreviations (cont)