Successful Treatment of Intrathecal Methotrexate Overdose by Using Ventriculolumbar Perfusion and Intrathecal Instillation of Carboxypeptidase G2 Aengus.

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Presentation transcript:

Successful Treatment of Intrathecal Methotrexate Overdose by Using Ventriculolumbar Perfusion and Intrathecal Instillation of Carboxypeptidase G2 Aengus S. O'Marcaigh, M.D., Christopher M. Johnson, M.D., William A. Smithson, M.D., Marc C. Patterson, M.D., Brigitte C. Widemann, M.D., Peter C. Adamson, M.D., Michael J. McManus, M.D. Mayo Clinic Proceedings Volume 71, Issue 2, Pages 161-165 (February 1996) DOI: 10.4065/71.2.161 Copyright © 1996 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Cerebrospinal fluid (CSF) and plasma methotrexate (MTX) concentrations after intrathecal (IT) overdose of MTX. CPDG2 = carboxypeptidase G2; HPLC = highperformance liquid chromatography. Mayo Clinic Proceedings 1996 71, 161-165DOI: (10.4065/71.2.161) Copyright © 1996 Mayo Foundation for Medical Education and Research Terms and Conditions