Oral immunotherapy–induced gastrointestinal symptoms and peripheral blood eosinophil responses  Michael R. Goldberg, MD, PhD, Arnon Elizur, MD, Liat Nachshon, MD, Michael Y. Appel, PhD, Michael B. Levy, MD, Keren Golobov, BScNutr, RD, Robert Goldberg, PhD, Miguel Stein, MD, Marc E. Rothenberg, MD, PhD, Yitzhak Katz, MD  Journal of Allergy and Clinical Immunology  Volume 139, Issue 4, Pages 1388-1390.e4 (April 2017) DOI: 10.1016/j.jaci.2016.09.053 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Receiver-operating characteristic curve evaluating the performance of max-AEC as a parameter for OITIGER diagnosis. Max-AEC values were categorized according to patient symptom status, and an empirical receiver-operating characteristic curve was generated. The asterisk (*) denotes the point of optimal sensitivity (85%) and specificity (73%), corresponding to a max-AEC value of 1140. Journal of Allergy and Clinical Immunology 2017 139, 1388-1390.e4DOI: (10.1016/j.jaci.2016.09.053) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Distribution of baseline eosinophil counts before OIT. Baseline counts were available for 565 of 794 (71%) patients. Each circle represents an individual patient. Journal of Allergy and Clinical Immunology 2017 139, 1388-1390.e4DOI: (10.1016/j.jaci.2016.09.053) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Eosinophil-specific increase during OIT. The percent of the total white blood cells at baseline and at max-AEC was tabulated for each respective cell type, and these results were averaged for OITIGER (n = 28) and asymptomatic patients (n = 251). Eos, Eosinophils; Neutro, neutrophils; Lymph, lymphocytes; Mono, monocytes. Journal of Allergy and Clinical Immunology 2017 139, 1388-1390.e4DOI: (10.1016/j.jaci.2016.09.053) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions