Phase 2 Treatment Naïve Injection Drug Use

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Presentation transcript:

Phase 2 Treatment Naïve Injection Drug Use Elbasvir-Grazoprevir in HCV GT 1,4, or 6 in PWID* on Opiate Agonist Therapy C-EDGE CO-STAR *PWID = Persons Who Inject Drugs Dore G, et al. AALSD. 2015; Abstract 40.

Primary End-Point: SVR12 Elbasvir-Grazoprevir in HCV GT 1, 4, or 6 in PWID on Opiate Agonist Therapy C-EDGE CO-STAR: Study Features C-EDGE CO-STAR Design: Randomized, phase 3, parallel group, placebo-controlled trial using a fixed-dose combination of elbasvir-grazoprevir in treatment-naïve chronic HCV genotype 1, 4, or 6 in persons who inject drugs who are receiving opiate agonist therapy Entry Criteria - Chronic HCV Genotype 1, 4, or 6 - No prior treatment - 18 years or older - Opiate Agonist Therapy for ≥3 months and kept ≥ 80% of appointments - HCV RNA ≥10,000 IU/mL - Cirrhosis allowed with goal 20% of subjects with cirrhosis - HIV infection allowed Primary End-Point: SVR12 Source: Dore G, et al. AALSD. 2015; Abstract 40.

Elbasvir-Grazoprevir in HCV GT 1, 4, or 6 in PWID on Opiate Agonist Therapy C-EDGE CO-STAR: Study Features Week 40 12 16 24 28 Treatment-naïve GT 1, 4 or 6 (N=301) Elbasvir-Grazoprevir- N=201 SVR12 Placebo Elbasvir-Grazoprevir- N=100 SVR12 Drug Dosing Grazoprevir-elbasvir (100/50 mg): fixed dose combination; one pill once daily Source: Dore G, et al. AALSD. 2015; Abstract 40.

C-EDGE CO-STAR: SVR12 Results with Full Analysis Set Elbasvir-Grazoprevir in HCV GT 1, 4, or 6 in PWID on Opiate Agonist Therapy C-EDGE CO-STAR: Results in Immediate Treatment Group C-EDGE CO-STAR: SVR12 Results with Full Analysis Set 184/201 144/154 28/30 11/12 1/5 *Includes one subject with mixed infection (GT 1a and 1b) who achieved SVR12 Source: Dore G, et al. AALSD. 2015; Abstract 40.

C-EDGE CO-STAR: SVR12 Results with Modified Full Analysis Set^ Elbasvir-Grazoprevir in HCV GT 1, 4, or 6 in PWID on Opiate Agonist Therapy C-EDGE CO-STAR: Results in Immediate Treatment Group C-EDGE CO-STAR: SVR12 Results with Modified Full Analysis Set^ 189/198 147/153 28/29 11/11 3/5 ^Excludes patients who discontinued trial for non-treatment related reasons *Includes one subject with mixed infection (GT 1a and 1b) who achieved SVR12 Source: Dore G, et al. AALSD. 2015; Abstract 40.

C-EDGE CO-STAR: SVR12 Results with Modified Full Analysis Set^ Elbasvir-Grazoprevir in HCV GT 1, 4, or 6 in PWID on Opiate Agonist Therapy C-EDGE CO-STAR: Results C-EDGE CO-STAR: SVR12 Results with Modified Full Analysis Set^ 151/158 38/40 83/85 106/113 83/85 106/113 Cirrhosis HCV RNA IU/ml Drug Screen ^Excludes patients who discontinued trial for non-treatment related reasons Source: Dore G, et al. AALSD. 2015; Abstract 40.

C-EDGE CO-STAR: Adherence Overall Elbasvir-Grazoprevir in HCV GT 1, 4, or 6 in PWID on Opiate Agonist Therapy C-EDGE CO-STAR: Results C-EDGE CO-STAR: Adherence Overall Source: Dore G, et al. AALSD. 2015; Abstract 40.

Elbasvir-Grazoprevir Elbasvir-Grazoprevir in HCV GT 1, 4, or 6 in PWID on Opiate Agonist Therapy C-EDGE CO-STAR: Safety Adverse Event (AE), n (%) Elbasvir-Grazoprevir Immediate (n=201) Deferred (Placebo) (n=100) Discontinuation due to AE 2 (1) 2 (2) Serious AEs 7 (3.5) 4 (4) Deaths 1 (1) Any AE in ≥10% of patients Fatigue Headache Nausea Diarrhea 166 (82.6) 32 (15.9) 26 (12.9) 23 (11.4) 20 (10) 83 (83) 20 (20) 14 (14) 9 (9) Laboratory AEs Hemoglobin <8.5 g/dl Late ALT/AST >5 x ULN* Bilirubin >2.6 x ULN* Creatinine >2.5 x baseline *ULN = upper limit of normal Source: Dore G, et al. AALSD. 2015; Abstract 40.

Elbasvir-Grazoprevir in HCV GT 1, 4, or 6 in PWID on Opiate Agonist Therapy C-EDGE CO-STAR: Conclusions Conclusions: “Elbasvir-grazoprevir demonstrated high efficacy in GT1 and 4- infected patients receiving Opiate Agonist Therapy. Data demonstrate support for treating HCV among subjects receiving Opiate Agonist Therapy.” Source: Dore G, et al. AALSD. 2015; Abstract 40.