The association of carotid plaque inflammation and Chlamydia pneumoniae infection with cerebrovascular symptomatology Elias A. Kaperonis, MD, Christos.

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Presentation transcript:

The association of carotid plaque inflammation and Chlamydia pneumoniae infection with cerebrovascular symptomatology Elias A. Kaperonis, MD, Christos D. Liapis, MD, John D. Kakisis, MD, Despina Perrea, MD, Alkiviadis G. Kostakis, MD, Panayotis E. Karayannakos, MD Journal of Vascular Surgery Volume 44, Issue 6, Pages 1198-1204 (December 2006) DOI: 10.1016/j.jvs.2006.08.029 Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 1 Anti-Chlamydia pneumoniae (Cp) immunoglobulin A (IgA) seropositivity in patients with symptomatic and asymptomatic carotid artery disease. Journal of Vascular Surgery 2006 44, 1198-1204DOI: (10.1016/j.jvs.2006.08.029) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 2 Chlamydia pneumoniae was detected much more often in the carotid plaques of symptomatic patients. IHC, Immunohistochemistry. Journal of Vascular Surgery 2006 44, 1198-1204DOI: (10.1016/j.jvs.2006.08.029) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 3 Tumor necrosis factor-α (TNF-α) plaque levels were significantly higher in symptomatic patients compared with asymptomatic patients. Especially in symptomatic anti-Chlamydia pneumoniae (Cp) immunoglobulin A (IgA) seropositive subjects, the levels of TNF-α on the atheroma were higher than in seronegative subjects, but the difference was not statistically significant (P = .056). Range bars indicate median and interquartile range and whiskers indicate outliers. Journal of Vascular Surgery 2006 44, 1198-1204DOI: (10.1016/j.jvs.2006.08.029) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 4 Immunohistochemistry of plaque specimens. A, Characteristically (red fast stain) stained plaque for the detection of Chlamydia pneumoniae by use of a specific monoclonal antibody for Chlamydia, an avidin-biotin complex, and alkaline phosphatase (magnification ×400), B, Atheroma negative for C pneumoniae (magnification ×200). Journal of Vascular Surgery 2006 44, 1198-1204DOI: (10.1016/j.jvs.2006.08.029) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 5 Immunoglobulin A (IgA) serum values in patients with Chlamydia pneumoniae (Cp) infected (IHC+) and non-infected (IHC–) plaques (P = .001, Mann-Whitney test). IHC, Immunohistochemistry. Range bars indicate median and interquartile range and whiskers indicate outliers. Journal of Vascular Surgery 2006 44, 1198-1204DOI: (10.1016/j.jvs.2006.08.029) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions