Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes.

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Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes by Aslihan Turhan, Pegah Jenab, Pierre Bruhns, Jeffrey V. Ravetch, Barry S. Coller, and Paul S. Frenette Blood Volume 103(6):2397-2400 March 15, 2004 ©2004 by American Society of Hematology

IVIG prevents both the interactions between sickle RBCs and WBCs and vaso-occlusion in sickle cell mice. IVIG prevents both the interactions between sickle RBCs and WBCs and vaso-occlusion in sickle cell mice. (A) IVIG reduces RBC-WBC interactions in vivo in a dose-dependent manner; differences were significant for the groups treated with IVIG at 200 mg/kg or more. #P ≤ .01 compared with PBS, P < .05 compared with the albumin-treated group. (B) IVIG 400 mg/kg improves centerline RBC velocities (VRBC) in venules as measured during IVM 1 in real time using an optical Doppler velocimeter (Texas A&M, College Station), and the effect is sustained after TNF-α (IVM 2). *P < .05 compared with the albumin group. #P< .05 compared with both the PBS and albumin groups. ¶Groups in which the numbers of live mice and venules were too small for reliable determination. (C) Representative still frames after TNF-α administration of venules from sickle cell mice treated with 1 mg/kg or 400 mg/kg IVIG. In venules of sickle mice treated with low-dose IVIG, there are numerous interactions between RBCs (black arrows) and adherent WBCs (white arrows) accompanied by drastic reductions in blood flow in most venules. Fewer RBC-WBC interactions and adherent WBCs are observed in sickle mice treated with high-dose IVIG. Scale bar indicates 10 μm. Movie segments corresponding to these still frames (C-D) can be viewed on the Blood website. See the Supplemental Video link at the top of the online article. Aslihan Turhan et al. Blood 2004;103:2397-2400 ©2004 by American Society of Hematology