R. Gao, M. Pan, X. Li, X. Zou, X. Zhao, T. Li, H. Yang, S. Zou, H

Slides:

Advertisements

Similar presentations

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

Advertisements

Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the.

Congenital cytomegalovirus infection: patterns of fetal brain damage

Long-term detection of seasonal influenza RNA in faeces and intestine

Copyright © 2017 American Academy of Pediatrics.

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

R. Cavallo Clinical Microbiology and Infection

Evolution of the incidence of hepatitis B virus infection and immunization rates in a large French cohort born between 1960 and 1994 C. Ramière, L. Roche,

Y. Huang, X.-F. Tian, X.-G. Fan, C.-Y. Fu, C. Zhu

A. Sultanova, M. Cistjakovs, S. Gravelsina, S. Chapenko, S. Roga, E

Comparison of the safety and immunogenicity of live attenuated and inactivated hepatitis A vaccine in healthy Chinese children aged 18 months to 16 years:

H. Lepidi, F. Gouriet, D. Raoult Clinical Microbiology and Infection

Influence of hepatitis C and hepatitis G virus co-infection on viral and cellular dynamics in patients infected with human immunodeficiency virus following.

Clinical Microbiology and Infection

Risk factors for cryptococcal infection among patients with rheumatoid arthritis receiving different immunosuppressive medications T.-L. Liao, Y.-M.

Migrant health—a cause for concern?

The relationship between tumour necrosis factor-α gene polymorphism and susceptibility and clearance of the persistent hepatitis B virus infection in.

Long-term detection of seasonal influenza RNA in faeces and intestine

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

An acute severe ehrlichiosis in a dog experimentally infected with a new virulent strain of Ehrlichia canis A. Unver, Y. Rikihisa, M. Karaman, H. Ozen

Epstein–Barr virus (EBV) DNA in whole blood as a superior prognostic and monitoring factor than EBV-encoded small RNA in situ hybridization in diffuse.

Paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis in China: a 5-year retrospective cohort study S. Yan,

Improvement in immune parameters and human immunodeficiency virus-1 viral response in individuals treated with 16α-bromoepiandrosterone (HE2000) C. Reading,

P. Castillo, C. Menéndez, A. Mayor, C. Carrilho, M. R. Ismail, C

A. F. Simonetti, C. Garcia-Vidal, D. Viasus, D. García-Somoza, J

Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface J. Croda,

Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection Y.W.

Y. -Y. Su, S. -J. Huang, M. Guo, J. Zhao, H. Yu, W. -G. He, H. -M

Individuals with inherited chromosomally integrated human herpes virus 6 (ciHHV-6) have functionally active HHV-6 specific T-cell immunity V. Strenger,

Comparison of the safety and immunogenicity of live attenuated and inactivated hepatitis A vaccine in healthy Chinese children aged 18 months to 16 years:

Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice? T. Coenye, D. Goeres, F. Van Bambeke, T. Bjarnsholt

Prevalence of Toscana virus antibodies in residents of Croatia

F. Li, P. Zhou, W. Deng, J. Wang, R. Mao, Y. Zhang, J. Li, J. Yu, F

Clinical Microbiology and Infection

N. Wu, Y. Huang, Q. Li, C. Bai, H.-D. Huang, X.-P. Yao

Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin- embedded skin biopsy specimens Usefulness of immunohistochemistry.

Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China Y. Wang, N. Zhu,

Persistence and reactivation of human adenoviruses in the gastrointestinal tract K. Kosulin, E. Geiger, A. Vécsei, W.-D. Huber, M. Rauch, E. Brenner,

High prevalence of early childhood infection by Kaposi's sarcoma-associated herpesvirus in a minority population in China Y. Cao, V. Minhas, X. Tan,

The added value of hepatitis E diagnostics in determining causes of hepatitis in routine diagnostic settings in the Netherlands M.H.E. Doting, J. Weel,

Campylobacter coli cultured from the stools of a patient with immunoproliferative small intestinal disease S. Coeuret, A. de La Blanchardière, V. Saguet-Rysanek,

Unexpectedly high prevalence of Treponema pallidum infection in the oral cavity of human immunodeficiency virus-infected patients with early syphilis.

Isospora belli Clinical Microbiology and Infection

Factors associated with subsequent nontuberculous mycobacterial lung disease in patients with a single sputum isolate on initial examination M.-R. Lee,

R. Karakus, K. Caglar, C. Aybay Clinical Microbiology and Infection

Performance of hepatitis C virus (HCV) direct-acting antivirals in clinical trials and daily practice J.E. Arends, P.A.M. Kracht, A.I.M. Hoepelman Clinical.

Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface J. Croda,

Corticosteroids for the treatment of human infection with influenza virus: a systematic review and meta-analysis J.-W. Yang, L.-C. Fan, X.-Y. Miao, B.

Human infection with H9N2 avian influenza in northern China

R. Bitterman, M. Paul, D. Polak, Y. Geffen

Detection of Wolbachia genes in a patient with non-Hodgkin's lymphoma

Lymphomatoid Granulomatosis: Past, Present,…Future?

Sexually acquired Zika virus: a systematic review

Systematic review of antibiotic consumption in acute care hospitals

Clinical microbiological case: severe relapsing septal panniculitis in a healthy man from the south-eastern USA A. Safdar, P.L. McEvoy, R.G. Burns, J.R.

The importance of strain variation in virulence of Candida dubliniensis and Candida albicans: results of a blinded histopathological study of invasive.

Accurate hepatitis C virus genotyping and selection of optimal therapy: lessons from a St Petersburg strain infection E. Knops, E. Heger Clinical Microbiology.

Vaccinations against respiratory tract infections at Hajj

H. Leblebicioglu, C. Eroglu Clinical Microbiology and Infection

Increased intrahepatic quasispecies heterogeneity correlates with off-treatment sustained response to nucleos(t)ide analogues in e antigen-positive chronic.

Immunohistochemical detection of Coxiella burnetii in an aortic graft

Dynamics of hepatitis B virus quasispecies heterogeneity in association with nucleos(t)ide analogue treatment determined by MALDI-TOF MS M. Rybicka,

The incidence and risk factors of invasive fungal infection after haploidentical haematopoietic stem cell transplantation without in vitro T-cell depletion

Nebulized hypertonic saline treatment in hospitalized children with moderate to severe viral bronchiolitis Z. Luo, Z. Fu, E. Liu, X. Xu, X. Fu, D. Peng,

M.T. Pérez-Rodríguez, A. Sousa, P. Martínez-Cueto, A. Ocampo

Modelling during an emergency: the 2009 H1N1 influenza pandemic

Enterococcal isolates carrying the novel oxazolidinone resistance gene optrA from hospitals in Zhejiang, Guangdong, and Henan, China, 2010–2014 J. Cai,

J.L. Balcázar Clinical Microbiology and Infection

Acquisition of second-line drug resistance and extensive drug resistance during recent transmission of Mycobacterium tuberculosis in rural China Y. Hu,

CMI readers' survey Clinical Microbiology and Infection

Presentation transcript:

Post-mortem findings in a patient with avian influenza A (H5N6) virus infection R. Gao, M. Pan, X. Li, X. Zou, X. Zhao, T. Li, H. Yang, S. Zou, H. Bo, J. Xu, S. Li, M. Zhang, Z. Li, D. Wang, S.R. Zaki, Y. Shu Clinical Microbiology and Infection Volume 22, Issue 6, Pages 574.e1-574.e5 (June 2016) DOI: 10.1016/j.cmi.2016.03.017 Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Histopathological findings in autopsy tissues. The histopathological features were determined by routine haematoxylin & eosin staining. Lung tissue of the patient showed diffused alveolar damage, including intra-alveolar oedema, extensive intra-alveolar haemorrhage, necrosis of alveolar lining cells, focal desquamation of pneumocytes in alveolar spaces, interstitial lymphocytes, phlogocyte and mononuclear inflammatory cell infiltrates (arrow) (a). Pulmonary vasculitis, which presented with oedema, and inflammation in vessel wall was observed in lung tissue (arrow) (b). Trachea presented focal denudation of the epithelium with oedema (arrow) (c), and lymphocyte infiltration was observed in mucosa (arrow) (d). Blood sinus expansion (arrow) and depletion of lymphocytes were observed in lung lymph gland (e). Spleen showed congestion (f). Brain showed oedema of neuroglial cells (five-pointed star) and focal neuronal degeneration in epencephala (g) and brainstem (arrow) (h). Liver presented hepatic spotty necrosis (arrow) accompanied by fatty degeneration in some hepatocytes (i). Lymphocyte infiltration (arrow) or anapetia (five-pointed star) presented in ileum (j) or rectum (k). Focal myocyte injury was observed in heart tissue (arrow) (l). Original magnification: ×20. Clinical Microbiology and Infection 2016 22, 574.e1-574.e5DOI: (10.1016/j.cmi.2016.03.017) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 The influenza nucleoprotein (NP) antigen distribution and viral load in selected autopsy tissues, innate immune cell infiltration and complement activation in lung tissues. Immunohistochemical staining with monoclonal antibody against NP showed positive stains (brown) scattered in pneumocytes of lung tissue (a). Sporadic stains presented in lymphocytes of pulmonary lymphoid gland (b) and spleen (c), epithelia of ileum (d) and rectum (e), hepatocytes (of liver) (f), neuron of epencephala (g) or epithelia of kidney (h). The diagram displayed quantification of the influenza virus matrix gene (log2 of the matrix gene/B2M housekeeping gene) in selected autopsy tissues (i). Highly abundant CD68+ (j) and scattered CD8+ T-cell infiltration (k) in alveolar tissue; cells with activated complement molecular C4d+ were scattered in alveolar (l) and pulmonary vascular (m) tissue; cells with activated complement C5a+ were extensively distributed in alveolar (n), and scattered in pulmonary vascular (o) tissue. Original magnifications: ×40 (a–h, j–l, n); ×20 (o); ×10 (m). Clinical Microbiology and Infection 2016 22, 574.e1-574.e5DOI: (10.1016/j.cmi.2016.03.017) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions