Applying proteomic technology to clinical virology

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Presentation transcript:

Applying proteomic technology to clinical virology C. Mancone, F. Ciccosanti, C. Montaldo, A.B. Perdomo, M. Piacentini, T. Alonzi, G.M. Fimia, M. Tripodi Clinical Microbiology and Infection Volume 19, Issue 1, Pages 23-28 (January 2013) DOI: 10.1111/1469-0691.12029 Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 MS-based proteomic workflow. Experimental proteomic analysis consists of several steps, listed in the different panels: sample preparation (i), protein or peptide mixture separation (ii), protein identification by MS (iii), and bioinformatic analysis (iv). 2-DE, two-dimensional gel electrophoresis. Clinical Microbiology and Infection 2013 19, 23-28DOI: (10.1111/1469-0691.12029) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Proteomic applications in virology research. Differential proteomics allows comparison of the abundance profiles of proteins isolated from different protein sources (left workflow). Structural and functional proteomics are performed to analyse viral-induced protein-protein interaction and post-translational modifications (PTMs) (right workflow). Specific bites: specific bound proteins; Vs: versus. Clinical Microbiology and Infection 2013 19, 23-28DOI: (10.1111/1469-0691.12029) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions