Autoimmune and inflammatory manifestations occur frequently in patients with primary immunodeficiencies Alain Fischer, MD, PhD, Johan Provot, MSc, Jean-Philippe.

Slides:

Advertisements

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Advertisements

A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada Moshe Ben-Shoshan, MD, Daniel W. Harrington, MA,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Defective B-cell memory in patients with Down syndrome Ruud H.J. Verstegen, MD, Gertjan J. Driessen, MD, Sophinus J.W. Bartol, BSc, Carel J.M. van Noesel,

Volume 60, Issue 2, Pages (August 2011)

Volume 136, Issue 1, Pages (July 2015)

Evaluation of basophil activation test in the management of immediate hypersensitivity reactions to gadolinium-based contrast agents: a five-year experience

Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study

Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome Marc Pineton de Chambrun, MD, Marie.

Pulmonary Arterial Hypertension Associated With Systemic Lupus Erythematosus Eric Hachulla, MD, PhD, Xavier Jais, MD, Gaël Cinquetti, MD, Pierre Clerson,

Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype Romain Micol, MD, MPH, PhD, Lilia Ben Slama, PhD, Felipe Suarez, MD,

Specific T cells for the treatment of cytomegalovirus and/or adenovirus in the context of hematopoietic stem cell transplantation Rita Creidy, PharmD,

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children Marie-Louise.

Physical health conditions and quality of life in adults with primary immunodeficiency diagnosed during childhood: A French Reference Center for PIDs.

Volume 60, Issue 2, Pages (August 2011)

Volume 153, Issue 1, Pages (January 2018)

Successful allogeneic hematopoietic stem cell transplantation for DOCK8 deficiency Vincent Barlogis, MD, Claire Galambrun, MD, Hervé Chambost, MD, Sylvie.

Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome Marc Pineton de Chambrun, MD, Marie.

Ann-Marie M. Schoos, MD, PhD, Jacob D

Disparities in allergic disease: Hypersensitivity and social disorders

PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator–dependent autoimmunity Anne-Laure Mathieu, PhD, Estelle Verronese,

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)‏

Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study

Is 9 more than 2 also in allergic airway inflammation?

Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition

Hospitalization rates and prognosis of patients with anaphylactic shock in Denmark from 1995 through 2012 Anni Nørgaard Jeppesen, MD, Christian Fynbo.

Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype Romain Micol, MD, MPH, PhD, Lilia Ben Slama, PhD, Felipe Suarez, MD,

Occurrence of myelodysplastic syndrome in 2 patients with reticular dysgenesis Chantal Lagresle-Peyrou, PhD, Bénédicte Neven, MD, Emmanuelle Six, PhD,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Outcome of domino hematopoietic stem cell transplantation in human subjects: An international case series Mirjam E. Belderbos, MD, PhD, Andrew R. Gennery,

Gut microbiome variations during hematopoietic stem cell transplant in severe combined immunodeficiency Jonathan P. Lane, MBBS, Christopher J. Stewart,

Gastrointestinal manifestations in mastocytosis: A study of 83 patients Harry Sokol, MD, PhD, Sophie Georgin-Lavialle, MD, PhD, Danielle Canioni, MD,

High-resolution computed tomography scan and airway remodeling in children with severe asthma Jacques de Blic, MD, Isabelle Tillie-Leblond, MD, PhD,

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Practice pattern changes and improvements in hematopoietic cell transplantation for primary immunodeficiencies Rebecca A. Marsh, MD, Kyle M. Hebert,

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes Anick Bérard, MSc, PhD, Odile Sheehy, MSc, Marie-Laure Kurzinger,

Evaluation of antithymocyte globulin pharmacokinetics and pharmacodynamics in children Naïm Bouazza, PhD, Saik Urien, MD, PhD, Bénédicte Neven, MD, Despina.

Genetic diagnosis of primary immunodeficiencies: A survey of the French national registry Nizar Mahlaoui, MD, PhD, Capucine Picard, MD, PhD, Perrine.

Gastrointestinal manifestations in mastocytosis: A study of 83 patients Harry Sokol, MD, PhD, Sophie Georgin-Lavialle, MD, PhD, Danielle Canioni, MD,

Infection with a respiratory virus before hematopoietic cell transplantation is associated with alloimmune-mediated lung syndromes Birgitta Versluys,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Combined liver and hematopoietic stem cell transplantation in patients with X-linked hyper-IgM syndrome Giorgia Bucciol, MD, Sarah K. Nicholas, MD, Pier.

Autophagy: Nobel Prize 2016 and allergy and asthma research

Staphylococcus aureus density on lesional and nonlesional skin is strongly associated with disease severity in atopic dermatitis Marie Tauber, MD, Stefana.

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Lauren A. DiTommaso, BS, Chen E. Rosenberg, MD, Michael D

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Persistence of natural killer cells with expansion of a hypofunctional CD56−CD16+KIR+NKG2C+ subset in a patient with atypical Janus kinase 3–deficient.

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study Francesca Ferrua, MD, Stefania.

Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia Romain.

CD45RA depletion in HLA-mismatched allogeneic hematopoietic stem cell transplantation for primary combined immunodeficiency: A preliminary study Fabien.

Sven Kracker, PhD, James Curtis, BSc, Mohammad A. A

Anaphylaxis during anesthesia in France: An 8-year national survey

Development of Churg-Strauss syndrome with controlled asthma during omalizumab treatment Anne-Marie Ruppert, MD, Gerlinde Averous, MD, Daniela Stanciu,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering a new century, do we do better?

Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis Philippe-Jean Bousquet, MD, Christophe Combescure, PhD,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Guus A. Westerhof, MD, Elise M. Vollema, MD, Els J

Asthma: The past, future, environment, and costs

Efficacy and safety of thalidomide in patients with inflammatory manifestations of chronic granulomatous disease: A retrospective case series Nicolas.

Confirmation and improvement of criteria for clinical phenotyping in common variable immunodeficiency disorders in replicate cohorts Helen Chapel, MA,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Escalating incidence of eosinophilic esophagitis: A 20-year prospective, population- based study in Olten County, Switzerland Petr Hruz, MD, PhD, Alex.

A neuropathological study of cerebrovascular abnormalities in a signal transducer and activator of transcription 3–deficient patient Marie-Olivia Chandesris,

Natural history of cow’s milk allergy

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Presentation transcript:

Autoimmune and inflammatory manifestations occur frequently in patients with primary immunodeficiencies Alain Fischer, MD, PhD, Johan Provot, MSc, Jean-Philippe Jais, MD, PhD, Alexandre Alcais, MD, PhD, Nizar Mahlaoui, MD, MSc, MPH Daniel Adoue, MD, Nathalie Aladjidi, MD, Zahir Amoura, MD, Philippe Arlet, MD, Corinne Armari-Alla, MD, Brigitte Bader-Meunier, MD, Vincent Barlogis, MD, Sophie Bayart, MD, Beatrice Beaurain, BS, Yves Bertrand, MD, PhD, Boris Bienvenu, MD, Stéphane Blanche, MD, Damien Bodet, MD, Bernard Bonnotte, MD, Raphaël Borie, MD, Patrick Boutard, MD, Claire Briandet, MD, Jean-Paul Brion, MD, Carolina Brito, MSc, Jacques Brouard, MD, Emilie Catherinot, MD, PhD, Olivia Chandesris, MD, Sarah Cohen-Beaussant, MD, Hélène Coignard-Biehler, MD, Laurence Costes, BS, Louis-Jean Couderc, MD, Gérard Couillault, MD, Virginie Courteille, BS, Elodie Curlier, MD, Geneviève de Saint Basile, MD, PhD, François Demeocq, MD, Nathalie de Vergnes, BS, Catherine Devoldere, MD, Anne Deville, MD, Jean Donadieu, MD, Eric Dore, MD, Fabienne Dulieu, MD, Isabelle Durieu, MD, Christine Edan, MD, Natacha Entz Werle, MD, Claire Fieschi, MD, PhD, Fanny Fouyssac, MD, Pierre Frange, MD, PhD, Vincent Gajdos, MD, PhD, Lionel Galicier, MD, Virginie Gandemer, MD, PhD, Martine Gardembas, MD, Catherine Gaud, MD, Bernard Grosbois, MD, Gaelle Guillerm, MD, Eric Hachulla, MD, Mohamed Hamidou, MD, Sébastien Héritier, MD, Olivier Hermine, MD, PhD, Cyrille Hoarau, MD, Bruno Hoen, MD, Arnaud Hot, MD, PhD, Sébastien Humbert, MD, Arnaud Jaccard, MD, Serge Jacquot, MD, Jean-Philippe Jais, MD, PhD, Rolland Jaussaud, MD, Pierre- Yves Jeandel, MD, Eric Jeziorski, MD, PhD, Kamila Kebaili, MD, Anne-Sophie Korganow, MD, Philippe Labrune, MD, Olivier Lambotte, MD, PhD, Fanny Lanternier, MD, PhD, Claire Larroche, MD, Alain Le Quellec, MD, Emmanuelle Le Moigne, MD, Vincent Le Moing, MD, Yvon Lebranchu, MD, Marc Lecuit, MD, PhD, Guillaume Lefevre, MD, Richard Lemal, MD, Philippe Le Moine, MD, Valérie Li Thiao Te, MD, Olivier Lortholary, MD, PhD, Patrick Lutz, MD, Aude Magerus-Chatinet, PhD, Marion Malphettes, MD, Aude Marie-Cardine, MD, Nicolas Martin Silva, MD, Agathe Masseau, MD, Christian Massot, MD, Françoise Mazingue, MD, Etienne Merlin, MD, Gérard Michel, MD, Frédéric Millot, MD, Odile Minckes, MD, Béatrice Monlibert, MD, Fabrice Monpoux, MD, PhD, Despina Moshous, MD, PhD, Luc Mouthon, MD, Martine Munzer, MD, Bénédicte Neven, MD, PhD, Raphaëlle Nove-Josserand, MD, Eric Oksenhendler, MD, PhD, Marie Ouachée-Chardin, MD, Anne Pagnier, MD, Jean-Louis Pasquali, MD, PhD, Marlène Pasquet, MD, Isabelle Pellier, MD, PhD, Yves Perel, MD, Antoinette Perlat, MD, Capucine Picard, MD, PhD, Christophe Piguet, MD, Dominique Plantaz, MD, Pierre Quartier, MD, Frédéric Rieux-Laucat, PhD, Pascal Roblot, MD, Pierre-Marie Roger, MD, Pierre-Simon Rohrlich, MD, Bruno Royer, MD, Valéry Salle, MD, Françoise Sarrot-Reynauld, MD, Amélie Servettaz, MD, Jean-Louis Stephan, MD, Nicolas Schleinitz, MD, Felipe Suarez, MD, PhD, Laure Swiader, MD, Sophie Taque, MD, Caroline Thomas, MD, Olivier Tournilhac, MD, Caroline Thumerelle, MD, Jean-Pierre Vannier, MD, Jean-François Viallard, MD Alain Fischer, MD, PhD, Johan Provot, MSc, Jean-Philippe Jais, MD, PhD, Alexandre Alcais, MD, PhD, Nizar Mahlaoui, MD, MSc, MPH Daniel Adoue, MD, Nathalie Aladjidi, MD, Zahir Amoura, MD, Philippe Arlet, MD, Corinne Armari-Alla, MD, Brigitte Bader-Meunier, MD, Vincent Barlogis, MD, Sophie Bayart, MD, Beatrice Beaurain, BS, Yves Bertrand, MD, PhD, Boris Bienvenu, MD, Stéphane Blanche, MD, Damien Bodet, MD, Bernard Bonnotte, MD, Raphaël Borie, MD, Patrick Boutard, MD, Claire Briandet, MD, Jean-Paul Brion, MD, Carolina Brito, MSc, Jacques Brouard, MD, Emilie Catherinot, MD, PhD, Olivia Chandesris, MD, Sarah Cohen-Beaussant, MD, Hélène Coignard-Biehler, MD, Laurence Costes, BS, Louis-Jean Couderc, MD, Gérard Couillault, MD, Virginie Courteille, BS, Elodie Curlier, MD, Geneviève de Saint Basile, MD, PhD, François Demeocq, MD, Nathalie de Vergnes, BS, Catherine Devoldere, MD, Anne Deville, MD, Jean Donadieu, MD, Eric Dore, MD, Fabienne Dulieu, MD, Isabelle Durieu, MD, Christine Edan, MD, Natacha Entz Werle, MD, Claire Fieschi, MD, PhD, Fanny Fouyssac, MD, Pierre Frange, MD, PhD, Vincent Gajdos, MD, PhD, Lionel Galicier, MD, Virginie Gandemer, MD, PhD, Martine Gardembas, MD, Catherine Gaud, MD, Bernard Grosbois, MD, Gaelle Guillerm, MD, Eric Hachulla, MD, Mohamed Hamidou, MD, Sébastien Héritier, MD, Olivier Hermine, MD, PhD, Cyrille Hoarau, MD, Bruno Hoen, MD, Arnaud Hot, MD, PhD, Sébastien Humbert, MD, Arnaud Jaccard, MD, Serge Jacquot, MD, Jean-Philippe Jais, MD, PhD, Rolland Jaussaud, MD, Pierre-Yves Jeandel, MD, Eric Jeziorski, MD, PhD, Kamila Kebaili, MD, Anne-Sophie Korganow, MD, Philippe Labrune, MD, Olivier Lambotte, MD, PhD, Fanny Lanternier, MD, PhD, Claire Larroche, MD, Alain Le Quellec, MD, Emmanuelle Le Moigne, MD, Vincent Le Moing, MD, Yvon Lebranchu, MD, Marc Lecuit, MD, PhD, Guillaume Lefevre, MD, Richard Lemal, MD, Philippe Le Moine, MD, Valérie Li Thiao Te, MD, Olivier Lortholary, MD, PhD, Patrick Lutz, MD, Aude Magerus-Chatinet, PhD, Marion Malphettes, MD, Aude Marie-Cardine, MD, Nicolas Martin Silva, MD, Agathe Masseau, MD, Christian Massot, MD, Françoise Mazingue, MD, Etienne Merlin, MD, Gérard Michel, MD, Frédéric Millot, MD, Odile Minckes, MD, Béatrice Monlibert, MD, Fabrice Monpoux, MD, PhD, Despina Moshous, MD, PhD, Luc Mouthon, MD, Martine Munzer, MD, Bénédicte Neven, MD, PhD, Raphaëlle Nove-Josserand, MD, Eric Oksenhendler, MD, PhD, Marie Ouachée-Chardin, MD, Anne Pagnier, MD, Jean-Louis Pasquali, MD, PhD, Marlène Pasquet, MD, Isabelle Pellier, MD, PhD, Yves Perel, MD, Antoinette Perlat, MD, Capucine Picard, MD, PhD, Christophe Piguet, MD, Dominique Plantaz, MD, Pierre Quartier, MD, Frédéric Rieux-Laucat, PhD, Pascal Roblot, MD, Pierre-Marie Roger, MD, Pierre-Simon Rohrlich, MD, Bruno Royer, MD, Valéry Salle, MD, Françoise Sarrot-Reynauld, MD, Amélie Servettaz, MD, Jean-Louis Stephan, MD, Nicolas Schleinitz, MD, Felipe Suarez, MD, PhD, Laure Swiader, MD, Sophie Taque, MD, Caroline Thomas, MD, Olivier Tournilhac, MD, Caroline Thumerelle, MD, Jean-Pierre Vannier, MD, Jean-François Viallard, MD Journal of Allergy and Clinical Immunology Volume 140, Issue 5, Pages 1388-1393.e8 (November 2017) DOI: 10.1016/j.jaci.2016.12.978 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Cumulative incidence of autoimmune/inflammatory manifestations in patients with PIDs as a function of age. Data are from 1678 patients for whom age at onset of first manifestation was recorded. Dotted lines indicate ± 2 SDs. Journal of Allergy and Clinical Immunology 2017 140, 1388-1393.e8DOI: (10.1016/j.jaci.2016.12.978) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Cumulative incidence of autoimmunity/inflammatory manifestations in patients with PIDs as a function of the PID disease group. Journal of Allergy and Clinical Immunology 2017 140, 1388-1393.e8DOI: (10.1016/j.jaci.2016.12.978) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Probability of survival of patients with PIDs as a function of the occurrence of autoimmune/inflammatory manifestations. Journal of Allergy and Clinical Immunology 2017 140, 1388-1393.e8DOI: (10.1016/j.jaci.2016.12.978) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Probability of survival of patients with PIDs after HSCT, according to the presence or absence of pre-existing autoimmunity/inflammation. Journal of Allergy and Clinical Immunology 2017 140, 1388-1393.e8DOI: (10.1016/j.jaci.2016.12.978) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Cumulative incidence of cytopenia, rheumatologic disorders, and autoimmune gastrointestinal manifestations as a function of age. A, Autoimmune cytopenia. B, Rheumatologic disorders. C, Gastrointestinal disorders. Journal of Allergy and Clinical Immunology 2017 140, 1388-1393.e8DOI: (10.1016/j.jaci.2016.12.978) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Survival of PID patients with CVID (A), other B-cell PIDs (B), T-cell PIDs (C), and innate PIDs (D) as a function of the occurrence of autoimmunity/inflammation. Journal of Allergy and Clinical Immunology 2017 140, 1388-1393.e8DOI: (10.1016/j.jaci.2016.12.978) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions