Scientific Discourse Task Tim Clark Massachusetts General Hospital & Harvard Medical School W3C HCLS F2F @ MIT April 30, 2009.

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Presentation transcript:

Scientific Discourse Task Tim Clark Massachusetts General Hospital & Harvard Medical School W3C HCLS F2F @ MIT April 30, 2009

Participants Uldis Bojars, Sean Bechhofer, John Breslin, Annamaria Carusi, Paolo Ciccarese, Tim Clark, Sudeshna Das, Tudor Groza, Christoph Lange, Scott Marshall, David Newman, Alex Passant, Eric Prud’hommeaux, Matthias Samwald, Susie Stephens, Elizabeth Wu, (and several others…)

What do these diseases have in common? Alzheimer Disease Huntington’s Disease Nicotine Addiction Schizophrenia Bipolar Disorder Autism Parkinson’s Disease ALS Neuropathic Pain Major Depressive Disorder Cancer (multiple forms)

Answer: Highly complex disorders Much information, incomplete understanding Inadequate treatment options Huge cost in human suffering Multi-factorial causality Require multi-disciplinary collaboration for progress to understanding and cure Productive disagreement drives research

Total annual cost = $895.2 billion

? ?

What is the underlying biology? Research Questions What is the underlying biology? How can we intervene therapeutically?

share interpretations create hypothesis design experiment run experiment collect data interpret data share interpretations synthesize knowledge

Scientific knowledge ecosystem run experiment collect data design experiment interpret data synthesize knowledge share interpretations create hypothesis Scientific knowledge ecosystem

Scientific Discourse Task Coalesce discourse ontologies SWAN + SIOC (+SALT?) Use in real applications (e.g. SCF/Drupal) Map over the research lifecycle Hypothesis, experiment, data Interpretation, publication, search Map with BioRDF, LODD & other tasks

Scientific Discourse Task Status April 30 2009 SWAN + SIOC Integration Done. IG Note in progress. Discourse + myExperiment Basic approach worked out. Discourse + Terminology Lightweight terminology bridging approach developed & to be presented at breakout.

Scientific Discourse Task Going forward Discourse + myExperiment Path to packaging data with pubs. Discourse + Terminology Path to agile development & support of scientific goals & legacy terminologies Discourse + Annotation Extensions to support annotation provenance & localization Discourse & web communities Jump into the primordial soup! :-)