Plasma concentrations and sedation scores after nebulized and intranasal midazolam in healthy volunteers A.S.M. McCormick, V.L. Thomas, D. Berry, P.W.

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Presentation transcript:

Plasma concentrations and sedation scores after nebulized and intranasal midazolam in healthy volunteers A.S.M. McCormick, V.L. Thomas, D. Berry, P.W. Thomas British Journal of Anaesthesia Volume 100, Issue 5, Pages 631-636 (May 2008) DOI: 10.1093/bja/aen072 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 Ramsay sedation scores in the nebulized and nasal groups [mean (2sem)]. Mean (sd) AUC: nebulized=163 (56.7), nasal=206 (60.1); P=0.005. British Journal of Anaesthesia 2008 100, 631-636DOI: (10.1093/bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Visual analogue scores in the nebulized and nasal groups [mean (2sem)]. Mean (sd) AUC: nebulized=3924 (932.1), nasal=2763 (663.9); P<0.001. British Journal of Anaesthesia 2008 100, 631-636DOI: (10.1093/bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 Critical flicker fusion frequency (Hz) [mean (2sem)]. Mean (sd) AUC: nebulized=1439 (430), nasal 966 (481); P=0.02. British Journal of Anaesthesia 2008 100, 631-636DOI: (10.1093/bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Oxygen saturations (%) [mean (2sem)]. Mean (sd) AUC: nebulized=5783 (46.5), nasal 5805 (53.9); P=0.32. British Journal of Anaesthesia 2008 100, 631-636DOI: (10.1093/bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 5 Systolic arterial pressure (mm Hg) [mean (2sem)]. Mean (sd) AUC: nebulized=6652 (1065.2), nasal=7089 (1022); P=0.07. British Journal of Anaesthesia 2008 100, 631-636DOI: (10.1093/bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 6 Diastolic arterial pressure (mm Hg) [mean (2sem)]. Mean (sd) AUC: nebulized=4031 (638.5), nasal=4494 (498.1); P=0.001. British Journal of Anaesthesia 2008 100, 631-636DOI: (10.1093/bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 7 Heart rate [mean (2sem)]. Mean (sd) AUC: nebulized=4235 (272.9), nasal=4526 (401.4); P=0.03. British Journal of Anaesthesia 2008 100, 631-636DOI: (10.1093/bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 8 Plasma midazolam concentrations (μg litre−1) [mean (2sem)]. Mean (sd) AUC: nebulized=1670 (778.0), nasal=4785 (1329.6); P<0.001. British Journal of Anaesthesia 2008 100, 631-636DOI: (10.1093/bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions