Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and.

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Presentation transcript:

Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study  Samuel B. Foster, MD, Kenneth McIntosh, MD, Bruce Thompson, PhD, Ming Lu, MS, Wanrong Yin, MS, Kenneth C. Rich, MD, Hermann Mendez, MD, Leslie K. Serchuck, MD, Clemente Diaz, MD, Mary E. Paul, MD, William T. Shearer, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 122, Issue 1, Pages 159-165 (July 2008) DOI: 10.1016/j.jaci.2008.04.043 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Survival analysis results for the time to first asthma medication use. Cox model estimates relating differences between children according to HIV infection status and HAART use (in the HIV+ group) and respective P values are annotated in the lower right-hand portion of the graph. Estimated cumulative incidences for each group at 2, 5, 10, and 13.5 years of age are annotated in the upper left-hand portion of the graph. Journal of Allergy and Clinical Immunology 2008 122, 159-165DOI: (10.1016/j.jaci.2008.04.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Prevalence of asthma medication use for children born in the pre-HAART era using GEEs. Data are presented by using a 3-point moving average. No asthma medications were used by any group before 60 months. Journal of Allergy and Clinical Immunology 2008 122, 159-165DOI: (10.1016/j.jaci.2008.04.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Median CD4+ T-cell percentages in children aged 6 to 10 years indexed according to the time of first asthma medication use (Time 0). The slope estimates of CD4+ T cell percentages from the mixed-model analysis are annotated in the upper portion of the graph. Journal of Allergy and Clinical Immunology 2008 122, 159-165DOI: (10.1016/j.jaci.2008.04.043) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions